SNCA基因rs356219和rs7684318位点多态性与帕金森病发病风险的Meta分析

Association of SNCA rs356219 and rs7684318 Polymorphisms with Risk of Parkinson′s Disease:A Meta-analysis

目的采用Meta分析评价α-突触核蛋白(SNCA)基因中rs356219和rs7684318位点多态性与亚洲和高加索人群帕金森病(PD)发病的相关性。方法检索PubMed、EMBASE、Cochrane、中国知网、万方数据库中涉及SNCA基因rs356219和rs7684318位点多态性与PD发病相关性的病例对照研究,检索时限为1990年1月1日至2019年7月15日,应用Stata 12.0软件进行Meta分析。结果共纳入16项符合要求的研究,包括7318例PD患者和8442例健康对照。rs356219位点的Meta分析结果显示,在所有遗传模型中,rs356219多态性与PD易感性显著相关(G vs A,OR=1.39,95%CI 1.29~1.50,P<0.001;AG vs AA,OR=1.36,95%CI 1.23~1.50,P<0.001;GG vs AA,OR=2.01,95%CI 1.76~2.29,P<0.001;AG+GG vs AA,OR=1.54,95%CI 1.40~1.69,P<0.001;GG vs AA+AG,OR=1.61,95%CI 1.42~1.83,P<0.001)。rs7684318位点的Meta分析显示,rs7684318位点多态性增加了亚洲人群PD发病的风险(C vs T,OR=1.46,95%CI 1.22~1.75,P<0.001;CC vs TT,OR=1.95,95%CI 1.51~2.52,P<0.001;TC vs TT,OR=1.62,95%CI 1.23~2.14,P=0.001;TC+CC vs TT,OR=1.78,95%CI 1.39~2.28,P<0.001)。结论SNCA基因rs356219多态性增加了亚洲人群和高加索人群PD的发病风险,而rs7684318多态性增加了亚洲人群PD的发病风险。

Objective To evaluate the association betweenα-synuclein(SNCA)(rs356219 locus and rs7684318 locus)polymorphism and the pathogenesis of Parkinson′s Disease(PD)in Asian and Caucasian populations by meta-analysis.Methods PubMed,EMBASE,Cochrane,CNKI and Wanfang data were searched for the literature of the SNCA(rs356219 and rs7684318)gene polymorphism and PD correlation case-control study published from Jan.1,1990 to Jul.15,2019,and the meta-analysis was performed using Stata 12.0 software.Results A total of 16 eligible studies were included in the study,including 7318 PD cases and 8442 controls.The meta-analysis showed that rs356219 polymorphism was significantly associated with PD susceptibility in all genetic models(G vs A,OR=1.39,95%CI 1.29-1.50,P<0.001;AG vs AA,OR=1.36,95%CI 1.23-1.50,P<0.001;GG vs AA,OR=2.01,95%CI 1.76-2.29,P<0.001;AG+GG vs AA,OR=1.54,95%CI 1.40-1.69,P<0.001;GG vs AA+AG,OR=1.61,95%CI 1.42-1.83,P<0.001).The rs7684318 locus meta-analysis showed that,rs7684318 polymorphism increased the risk of PD in Asian populations(C vs T,OR=1.46,95%CI 1.22-1.75,P<0.001;CC vs TT,OR=1.95,95%CI 1.51-2.52,P<0.001;TC vs TT,OR=1.62,95%CI 1.23-2.14,P=0.001;TC+CC vs TT,OR=1.78,95%CI 1.39-2.28,P<0.001).Conclusion The SNCA(rs356219)polymorphism increases the risk of PD in Asian and Caucasian populations,and the rs7684318 polymorphism increases the risk of PD in Asian populations.