氟哌噻吨美利曲辛联合常规治疗对慢性阻塞性肺疾病急性加重期患者焦虑抑郁症状及生活质量的影响

Effect of Flupentixol-Melitracen Combined with Routine Therapy on Anxiety and Depression Symptoms and Quality of Life in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨氟哌噻吨美利曲辛联合常规治疗对慢性阻塞性肺疾病(COPD)急性加重期患者焦虑抑郁症状及生活质量的影响。方法收集2016年1月至2018年1月东莞市人民医院全科医学科收治的116例伴焦虑抑郁症状COPD急性加重期患者的病例资料,根据治疗方法不同分为对照组和观察组,各58例。对照组采用抗焦虑抑郁治疗,观察组采用抗焦虑抑郁联合氟哌噻吨美利曲辛治疗,均治疗2周。观察两组的临床疗效,治疗前后焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、生活质量(CAT)评分、呼吸困难程度[呼吸困难量表(MMRC)]变化。结果观察组治疗总有效率显著高于对照组[93.10%(54/58)比67.24%(39/58)](P<0.05)。SAS、SDS评分的时点间与组间存在交互作用(P<0.05),治疗后两组SAS、SDS评分均显著降低,且观察组患者焦虑、抑郁改善程度优于对照组(P<0.05);CAT、MMRC评分的时点间与组间存在交互作用(P<0.05),治疗后两组CAT、MMRC评分均显著降低,且观察组CAT、MMRC评分改善显著优于对照组(P<0.05)。结论氟哌噻吨美利曲辛联合常规治疗能够缓解COPD急性加重期焦虑抑郁患者的焦虑抑郁症状,提高患者生活质量。

Objective To investigate the effect of flupentixol-melitracen combined with conventional therapy on anxiety and depression symptoms and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 116 patients with acute exacerbation of COPD with anxiety and depression symptoms admitted to the General Practice Medicine Department of Dongguan People′s Hospital from Jan.2016 to Jan.2018 were included and divided into a control group(anti-anxiety and depression treatment,58 cases)and an observation group(anti-anxiety and depression treatment+flupentixol-melitracen,58 cases)according to different treatment schemes,both of which were treated for 2 weeks.The clinical efficacy of the two groups was observed.The changes and differences of self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score,COPD assessment test(CAT)score and dyspnea degree[modified medical research council dyspnea scale(MMRC)]were of two groups before and after treatment were observed.Results The total effective rate of the observation group was significantly higher than that of the control group[93.10%(54/58)vs 67.24%(39/58)](P<0.05).There were interactions in the SAS and SDS scores between groups and time points(P<0.05),and the SAS and SDS scores of both groups were significantly reduced after treatment,and the anxiety and depression of the observation group were improved more significantly than in the control group(P<0.05);there was interactions in CAT and MMRC scores between groups and time points(P<0.05),the CAT and MMRC scores of the two groups after treatment were significantly decreased,and the improvement of CAT and MMRC scores in the observation group was significantly better than that in the control group(P<0.05).Conclusion Flupentixol-melitracen combined with conventional treatment can relieve anxiety and depression symptoms of patients with acute exacerbation of COPD and improve their quality of life.