后抗生素时代的辅助抗菌策略研究进展

Advances of Assisted Antimicrobial Strategies in the Post-Antibiotic Era

随着细菌耐药问题的逐年加剧,新型抗生素的研发进度已经不能满足日益紧迫的临床用药需求。因此,能够与传统抗生素配合使用,有效提高其治疗效率的新型辅助抗菌策略正逐渐成为最近几年的研究热点。简要介绍了几种较为经典的辅助抗菌策略,并对其作用机制和发展现状进行总结。

With the increasing bacterial resistance in recent years,the research and development of new antibiot⁃ics can not meet the needs of clinical use.Therefore,new alternative therapie strategies that can be used with tra⁃ditional antibiotics for improve their therapeutic efficiency are becoming the focus of research in recent years.We introduced several classical antibacterial strategies,and summarized their mechanism of action and development sta⁃tus quo.