TIGIT在消化系统肿瘤中免疫应答作用研究进展

Advance of the Immune Response of TIGIT in Digestive System Tumors

T细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域(TIGIT)是表达在NK细胞和T细胞表面的一种免疫抑制性受体,可与细胞表面相应的配体结合,激活细胞内的负性调节信号,抑制机体免疫系统的激活,从而发挥免疫抑制作用。TIGIT在肿瘤性、感染性及自身免疫性疾病的发病过程中起重要作用。本文就TIGIT在消化系统肿瘤中的免疫应答作用研究进展进行综述。

T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain(TIGIT)is an im⁃munosuppressive receptor expressed on the surface of NK cells and T cells.TIGIT can exert an immunosuppres⁃sive effect by binding with the corresponding ligands on the cell surface,activating the negative regulatory signals in the cells and inhibiting the activation of the immune system.TIGIT plays an important role in the pathogenesis of tumor,infectious and autoimmune diseases.The current article reviewed the advance of the immune response of TIGIT in digestive system tumors.