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内质网应激在炎症性肠病免疫调节中的作用 被引量:3

Role of endoplasmic reticulum stress in immune regulation of inflammatory bowel disease
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摘要 炎症性肠病(IBD)患者的肠道免疫系统失衡,引起肠黏膜屏障损伤,从而导致持续的非特异性炎性反应。研究显示,内质网应激(ERS)是IBD的发病机制之一。ERS使细胞内功能蛋白质产生减少,若ERS持续存在或过于严重,会导致细胞凋亡及炎性反应加重。研究显示ERS可能参与了免疫反应并导致肠道免疫系统失衡,且这一过程可能涉及模式识别受体(PRR)及炎性细胞因子。该文就ERS在IBD患者的免疫炎性反应中的作用作一综述。
作者 胡甜 申月明 曾亚 HU Tian;SHEN Yueming;ZENG Ya
出处 《国际消化病杂志》 CAS 2021年第1期15-18,44,共5页 International Journal of Digestive Diseases
基金 湖南省自然科学基金资助项目(2019JJ40319) 湖南省卫生健康委课题项目(B2019142)。
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