肠道微生物在放射性肠损伤及其治疗中的研究进展

Research progress of intestinal microbiota in radiation-induced intestinal injury and treatment

放射性肠损伤(RIII)是腹盆腔肿瘤放疗中常见的不良反应,严重影响着癌症患者的后续治疗计划和幸存者的生活质量,其患病人数已远超炎症性肠病,亟需有效的防治措施。已有大量研究结果证明,RIII与肠道微生物群失调相关,而粪菌移植(FMT)可以帮助患者恢复肠道微生物群的丰度和多样性,可以作为RIII治疗中的潜在方法。笔者着重综述了肠道微生物在RIII发生和发展过程中的作用及其机制,以及FMT在RIII治疗中的应用。

As the common side effect of radiotherapy for abdominal and pelvic tumors,radiation-induced intestinal injury(RIII)has seriously affected the subsequent therapy for cancer patients and the life quality of survivors.The number of patients with RIII are far exceeded those with inflammatory bowel disease,and there is an urgent need for effective treatment.Evidence supporting a pivotal role of the gut microbiota in the development of RIII has been growing.Fecal microbiota transplantation(FMT)has been confirmed to restore the abundance and diversity of patients'microbiota,and has become a potential method in the treatment of RIII.In this review,we put foward our current understanding of the role and mechanism of intestinal microbes in RIII and the application of FMT in the treatment of RIII.