Contradictory effect of gold nanoparticle-decorated molybdenum sulfide nanocomposites on amyloid-β-40 aggregation

The effect of gold nanoparticle-decorated molybdenum sulfide(AuNP-MoS2)nanocomposites on amyloid-β-40(Aβ40)aggregation was investigated.The interesting discovery was that the effect of AuNPMoS2 nanocomposites on Aβ40 aggregation was contradictory.Low concentration of AuNP-MoS2 nanocomposites could enhance the nucleus formation of Aβ40 peptides and accelerate Aβ40 fibrils aggregation.However,although high concentration of AuNP-MoS2 nanocomposites could enhance the nucleus formation of Aβ40 peptides,it eventually inhibited Aβ40 aggregation process.It might be attributed to the interaction between AuNP-MoS2 nanocomposites and Aβ40 peptides.For low concentration of AuNP-MoS2 nanocomposites,it was acted as nuclei,resulting in the acceleration of the nucleation process.However,the structural flexibility of Aβ40 peptides was limited as the concentration of AuNP-MoS2 nanocomposites was increased,resulting in the inhibition of Aβ40aggregation.These findings suggested that AuNP-MoS2 nanocomposites might have a great potential to design new multifunctional material for future treatment of amyloid-related diseases.