高血压幽门螺杆菌感染患者血清IL-18、TGF-β1、salusin-α表达变化及意义

Changes in the expression levels of serum IL-18, TGF-β1 and Salusin-α and their significance in Patients with hypertension Hp infection

目的探讨高血压幽门螺杆菌(Hp)感染患者血清白细胞介素-18(IL-18)、转化生长因子-β1(TGF-β1)、心血管活性肽-α(salusin-α)表达及意义。方法选取2016年8月-2019年7月河北医科大学第四医院94例高血压患者作为研究对象,经Hp检测分为两组,Hp阳性组42例,Hp阴性组52例。对比两组及不同高血压分级患者血清IL-18、TGF-β1、salusin-α、Hp-IgG水平,分析上述血清因子表达与Hp抗体(Hp-IgG)相关性及联合检测对高血压Hp感染的诊断价值。结果随着高血压分级升高,血清IL-18、TGF-β1、Hp-IgG水平呈升高趋势,血清salusin-α水平呈降低趋势(P<0.05);血清IL-18、TGF-β1水平与Hp-IgG水平呈正相关,血清salusin-α水平与Hp-IgG水平呈负相关关系(P<0.05);Hp阳性组血清IL-18、TGF-β1水平高于Hp阴性组,salusin-α水平低于Hp阴性组(P<0.05);血清IL-18、TGF-β1、salusin-α联合诊断高血压Hp感染的AUC值为0.869,优于IL-18、TGF-β1、salusin-α单独诊断(P<0.05)。结论血清IL-18、TGF-β1、salusin-α表达与高血压病情进展及Hp感染关系密切,联合检测可进一步提高诊断敏感性,为临床完善诊治依据提供参考。

OBJECTIVE To investigate the expression and significance of serum interleukin-18(IL-18), transforming growth factor-β1(TGF-β1) and salusin-α(salusin-α) in patients with hypertensive Helicobacter pylori(Hp) infection. METHODS A total of 94 patients with hypertension in the fourth hospital of Hebei Medical University from Aug. 2016 to Jul. 2019 were recruited as the research subjects. They were divided into the two groups according to the results of Hp test: 42 cases were in the Hp positive group and 52 cases were in the Hp negative group. The serum levels of IL-18, TGF-β1, salusin-α and Hp-IgG in patients with different hypertension grades between the two groups were compared, the correlation between the indexes and Hp antibody(Hp-IgG) were evaluated and the diagnostic value of combined detection for Hp infection in hypertension were analyzed. RESULTS The serum IL-18, TGF-β1 and Hp-IgG levels increased but the serum salusin-α level decreased with the increase of hypertension grade(P<0.05);serum IL-18 and TGF-β1 levels were positively correlated with Hp-IgG levels, whereas serum salusin-α levels were negatively correlated with Hp-IgG levels(P<0.05);serum IL-18 and TGF-β1 levels in the Hp-positive group were higher than that in the Hp-negative group, and salusin-α levels were lower than that in the Hp-negative group(P<0.05). The AUC value of the combined detection of serum IL-18, TGF-β1 and salusin-α in the diagnosis of hypertension Hp infection was 0.869, which was better than that of single detection(P<0.05). CONCLUSION Serum IL-18, TGF-β1 and salusin-α expression are closely related to the progression of hypertension and Hp infection, and combined detection can further improve the diagnostic sensitivity and provide a reference for improving the clinical diagnosis and treatment basis.