摘要
目的:探讨壮腰通络方治疗腰椎间盘突出症(肝肾亏虚、瘀血阻络证)的临床疗效和安全性。方法:采用壮腰通络方内服治疗45例(肝肾亏虚、瘀血阻络证)腰椎间盘突出症患者,疗程4周,分别于治疗前、治疗2周后、治疗4周后及治疗结束后2周随访时记录患者JOA评分、腰痛VAS评分及中医证候积分,并观察用药安全性。结果:患者的JOA评分、VAS评分及中医证候积分在治疗2周后、治疗4周后及治疗结束后2周随访与治疗前比较,差异均有统计学意义(P<0.05);治疗4周后及治疗结束后2周随访与治疗2周后比较,差异有统计学意义(P<0.05)。在JOA评分中,主观症状评分及日常活动受限程度评分在治疗2周后、治疗4周后及治疗结束后2周随访与治疗前比较,差异均有统计学意义(P<0.05);治疗4周后及治疗结束后2周随访与治疗2周后比较,差异有统计学意义(P<0.05);而临床体征评分仅在治疗4周后及治疗结束后2周随访与治疗前比较,差异均有统计学意义(P<0.05)。经过治疗2周及治疗4周后,JOA疗效评价有效率分别为77.78%和82.22%;在治疗结束后2周随访时,有效率为80%。在观察期内未发现因服用本药而引起的不良事件。结论:壮腰通络方能改善腰椎间盘突出症(肝肾亏虚、瘀血阻络证)患者腰膝酸软等中医证候积分及主观症状、日常活动受限程度等腰椎功能评分,具有较稳定的临床疗效和安全性。
Objective:To explore the clinical efficacy and safety of Zhuangyao Tongluo decoction in the treatment of lumbar disc herniation(LDH)of liver-kidney deficiency,blood stasis syndrome.Methods:45patients with LDH were treated with Zhuangyao Tongluo decoction for 4weeks.JOA scores,VAS scores,traditional Chinese medicine(TCM)syndrome scores and drug safety were recorded before treatment,2weeks,4 weeks after treatment and 2 weeks’follow-up.Results:Compared with those before treatment,JOA scores,VAS scores and TCM syndrome scores were respectively significantly changed at 2weeks,4weeks after treatment and 2 weeks’follow-up(P<0.05).Compared with those of 2 weeks after treatment,there were significant differences after 4weeks treatment and 2weeks of follow-up(P<0.05).In terms of clinical sign scores,compared with that before treatment,there was significant difference after 4weeks of treatment and 2weeks of follow-up(P<0.05).After 2weeks and 4weeks treatment,the effective rates of JOA efficacy evaluation were 77.78%and 82.22%respectively.The effective rate was 80%after 2weeks’follow-up.During the observation period,there was no side-effects caused by medication.Conclusion:Zhuangyao Tongluo decoction can effectively improve the scores of TCM syndromes such as sore waist and knees of patients with LDH of liver-kidney deficiency,blood stasis syndrome,and can also improve the scores of lumbar function such as subjective symptoms and limits of daily activities,which has stable clinical efficacy and safety.
作者
孙凯
朱立国
魏戌
银河
杨克新
高景华
杨博文
齐保玉
唐彬
陈琳
秦晓宽
谭贵红
SUN Kai;ZHU Liguo;WEI Xu;YIN He;YANG Kexin;GAO Jinghua;YANG Bowen;QI Baoyu;TANG Bin;CHEN Lin;QIN Xiaokuan;TAN Guihong(Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;Beijing Key Laboratory of Orthopedics of Traditional Chinese Medicine,Beijing 100007,China;Beijing University of Traditional Chinese Medicine,Beijing 100029,China.)
出处
《中国中医骨伤科杂志》
CAS
2021年第1期19-23,共5页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
中国中医药循证能力提升建设项目(ZZ13-024-7)
中国中医科学院“十三五”重点领域科研项目(ZZ10-022)
中国中医科学院优秀青年科技人才(创新类)培养专项计划(ZZ13-YQ-039)。
关键词
腰椎间盘突出症
壮腰通络方
临床观察
lumbar disc herniation
Zhuangyao Tongluo decoction
clinical observation