益生菌对慢性乙肝肝硬化患者免疫功能及肠道菌群的影响

Influence of probiotics on the immune function and intestinal flora of patients with chronic hepatitis B cirrhosis

目的:研究益生菌对慢性乙肝肝硬化患者免疫功能及肠道菌群的影响。方法:100例慢性乙肝肝硬化患者,按照随机数表法均分为两组,每组各50例。对照组采用常规治疗,观察组在对照组基础上给予益生菌治疗。测定并比较两组患者治疗前后的肠道菌群、肝功能、炎症因子水平及血清内毒素水平。结果:治疗后,观察组双歧杆菌、嗜酸杆菌及梭菌含量均高于对照组,肠杆菌和肠球菌含量低于对照组(P<0.05),ALT、AST及TBIL水平均低于对照组(P<0.05),IL-10、TNF-α及内毒素水平均低于对照组(P<0.05)。观察组NK、CD3及CD4水平均高于对照组(P<0.05)。结论:益生菌治疗慢性乙肝肝硬化疗效显著,能够促进患者肠道有益菌增加,改善患者的免疫功能和肝功能,值得临床推广。

Objective:To study the influence of probiotics on the immune function and intestinal flora of patients with chronic hepatitis B cirrhosis.Methods:100 patients with chronic hepatitis B cirrhosis were selected as the subjects and divided into two groups according to the random number table method,50 cases in each group.The patients in the control group were treated routinely.The patients in the observation group were given probiotic treatment on the basis of the control group.The intestinal flora,liver function,inflammatory factor levels and serum endotoxin levels of the two groups of patients were measured and compared before and after treatment.Results:After treatment,the content of Bifidobacterium,Acidophilus and Clostridium in the observation group were significantly higher than that in the control group,and the content of Enterobacteriaceae and Enterococcus were significantly lower than that in the control group(P<0.05).The ALT,AST and TBIL levels of the observation group were significantly lower than those of the control group(P<0.05),and the levels of IL-10,TNF-αand endotoxin were also significantly lower than those of the control group(P<0.05),the levels of NK,CD3 and CD4 of the observation group were significantly higher than those of the control group(P<0.05).Conclusion:Probiotics are effective in the treatment of chronic hepatitis B liver cirrhosis,which can promote the increase of beneficial bacteria in patients'intestines and improve the patients'immune function and liver function,it is worthy of clinical promotion.