固肾方在慢性肾脏病3~4期脾肾气虚证患者中的应用

Application of Gushen Recipe in patients with spleen-kidney qi deficiency syndrome of chronic kidney disease stage 3 and 4

目的探讨固肾方在慢性肾脏病3~4期脾肾气虚证患者中的应用。方法选取2018年1—12月在苏州市中西医结合医院肾病科门诊就诊以及住院治疗的慢性肾脏病3~4期脾肾气虚证患者60例为研究对象,随机数字法分为,对照组和研究组,每组各30例。对照组应用常规治疗,研究组在此基础上应用固肾方治疗,对比两组应用不同方法治疗后对患者血肌酐、24 h蛋白尿、血清胱抑素C、肾小球过滤指标、治疗有效率及不良反应发生的影响。结果研究组治疗后血肌酐为(124.85±14.08)μmol/L、24 h蛋白尿为(1.87±0.74)g及血清胱抑素C为(0.75±0.19)mg/L指标均低于对照组血肌酐为(136.14±13.72)μmol/L、24 h蛋白尿为(2.63±0.55)g及血清胱抑素C为(0.99±0.21)mg/L(P<0.05),肾小球过滤为(50.83±7.48)(min·1.73 m^(2))指标高于对照组肾小球过滤为(45.13±8.04)(min·1.73 m^(2))(P<0.05);研究组治疗总有效率(90.0%)高于对照组(70.0%)(P<0.05)。结论在对慢性肾脏病3~4期脾肾气虚证的治疗过程中,固肾方的治疗效果理想,能够有效改善患者的肾功能,提高治疗效果,同时加用固肾方也没有出现不良反应,用药的安全性较高,临床上应当进一步推广应用。

Objective To explore the application of Gushen Recipe in patients with spleen and kidney qi deficiency syndrome of chronic kidney disease stage 3 and 4.Methods Sixty outpatients and inpatients with spleen and kidney qi deficiency syndrome who were treated in the department of the nephrology department of Suzhou Hospital of Integrated Traditional Chinese and Western Medicine for chronic kidney disease stage 3 and 4 were selected as the research objects from January to December 2018.The patients were divided into two groups according to the random number method,including the control group(n=30)and the study group(n=30).The control group was treated with conventional treatment,and the study group was treated with Gushen Recipe on this basis.The effects of different treatment methods on patients'serum creatinine,24 h proteinuria,serum cystatin C,glomerular filtration indicators,treatment efficiency and adverse reactions between the two groups were compared.Results After treatment,the serum creatinine was(124.85±14.08)μmol/L,24 h proteinuria was(1.87±0.74)g and serum cystatin C was(0.75±0.19)mg/L indexes of the study group were lower than those of the control group([136.14±13.72]μmol/L,[2.63±0.55]g and[0.99±0.21]mg/L,P<0.05).The glomerular filtration was(50.83±7.48)(min·1.73 m^(2))index was higher than that([45.13±8.04][min·1.73 m^(2)])in the control group(P<0.05).The effective rate of treatment in the study group was 90.0%higher than that in the control group(70.0%)(P<0.05).Conclusion During the treatment of spleen-kidney qi deficiency syndrome of chronic kidney disease stage 3 and 4,Gushen Recipe has an ideal therapeutic effect,which can effectively improve the patient's renal function and improve the therapeutic effect.At the same time,the addition with Gushen Recipe has no adverse reactions.It is safe and should be further promoted and applied clinically.