乳腺癌MRI表现与血清肿瘤标志物的相关性分析

Correlation between MRI Findings of Breast Cancer and Serum Tumor Markers

目的探讨乳腺癌磁共振成像(MRI)表现与血清肿瘤标志物的相关性。方法回顾性分析2016年1月至2019年10月医院收治的280例原发性乳腺癌患者的MRI影像学资料,分析MRI形态学表现;同时收集乳腺癌患者血清肿瘤标志物包括乳腺癌相关抗原(CA153)、卵巢癌相关抗原(CA125)、癌胚抗原(CEA)的检测结果 ,分析乳腺癌MRI表现与3种血清种肿瘤标志物的关系。结果经Pearson相关分析,MRI检查显示肿瘤直径≥2cm的乳腺癌患者血清CA153、CA125、CEA的阳性表达率高于肿瘤直径<2cm的患者(P<0.05);合并淋巴结转移的乳腺癌患者血清CA153、CA125、CEA的阳性表达率高于未合并淋巴结转移的患者(P<0.05)。MRI影像学检查中,不同肿瘤形态、肿瘤边缘、强化方式、强化曲线的乳腺癌患者血清CA153、CA125、CEA表达比较,差异无统计学意义(P>0.05)。结论肿瘤直径≥2cm、合并淋巴结转移与乳腺癌患者血清CA153、CA125、CEA的阳性表达率有一定相关性。

Objective To explore the correlation between magnetic resonance imaging(MRI) findings of breast cancer and serum tumor markers.Methods MRI imaging data of 280 patients with primary breast cancer admitted to the hospital from January 2016 to October 2019 were retrospectively analyzed.MRI morphological manifestations were analyzed.The test results of serum tumor markers in breast cancer patients we re collected,in cluding breast cancer-related antigen(CA153),ovarian cancerrelated antigen(CA125),and carcinoembryonic antigen(CEA).The relationship between MRI findings of breast cancer and the three serum tumor markers was analyzed.Results After Pearson correlation analysis,MRI examination showed that favora ble expression rates of serum CA153,CA125 and CEA in breast cancer patients with tumor diameter not shorter than 2 cm were higher than those shorter than2 cm(P<0.05).The positive expression rates of serum CA153,CA125 and CEA in breast cancer patients with lymph node metastasis were higher than those without lymph node metastasis(P<0.05).There was no significant difference in expression of serum CA153,CA125,and CEA among breast cancer patients with different tumor morphology,tumor margin,enhancement methods,and enhancement curves(P>0.05)in MRI imaging examination.Conclusion Tumor diameter not shorter than 2 cm and lymph node metastasis are correlated with positive expression rates of serum CA153,CA125,and CEA in breast cancer patients.