彩色多普勒超声、MSCT联合血清HFA检测诊断卵巢恶性肿瘤的价值观察

Value of Color Doppler Ultrasound,MSCT Combined with Serum HFA Detection in the Diagnosis of Malignant Ovarian Tumors

目的探究彩色多普勒超声、多层螺旋CT(MSCT)联合血清人附睾上皮分泌蛋白4(HFA)检测诊断卵巢恶性肿瘤的应用价值。方法回顾性分析2016年9月至2018年9月就诊于我院妇产科经手术治疗且术后病理诊断为卵巢肿瘤的68例临床病例,术前均进行彩色多普勒超声、MSCT检查。另选取同期我院体检中心体检的30例健康志愿者为对照组,检测并比较各组血清HFA水平。以病理结果为金标准,绘制ROC曲线,计算ROC曲线下面积(AUC)分析诊断效能。结果恶性组血清HFA水平显著高于良性组与对照组,差异有统计学意义(P<0.05);而良性组与对照组血清HFA水平比较差异无统计学意义(P>0.05);彩色多普勒超声、MSCT、血清HFA检测及其三者联合诊断卵巢恶性肿瘤的AUC分别为0.833、0.906、0.789、0.938,彩色多普勒超声、MSCT联合血清HFA检测诊断卵巢恶性肿瘤的AUC显著高于单独诊断。结论彩色多普勒超声、MSCT、血清HFA检测三者联合诊断可显著提高诊断敏感度与准确性,作为卵巢恶性肿瘤诊断的有效手段,可为患者临床诊疗方案提供依据。

Objective To investigate the application value of color Doppler ultrasound,multi-slice spiral CT(MSCT)combined with serum human epididymis secretory protein 4(HFA) detection in the diagnosis of malignant ovarian tumors.Methods The clinical cases of 68 patients undergoing surgical treatment and with ovarian tumors by postoperative pathological diagnosis in the obstetrics and gynecology department of the hospital from September 2016 to September 2018 were retrospectively analyzed,all of them were given color Doppler ultrasound and MSCT examination before surgery.Besides,30 healthy volunteers from the physical examination center of the hospital in the same period were selected as the control group.The serum HFA levels of each group were detected and compared.Taking the Pathologic diagnosis was applied as the gold standard,the ROC curve was drawn,the area under the ROC curve(AUC) was calculated;the diagnostic efficiency was analyzed.Results The serum HFA level in the malignant group was significantly higher than that in the benign and control groups(P<0.05).There was no significant difference in the serum HFA level between the benign and control groups(P>0.05).The AUC for diagnosing malignant ovarian tumors by color Doppler ultrasound,MSCT,serum HFA and the combination of the three were 0.833,0.906,0.789,and 0.938,respectively.The AUC for diagnosing malignant ovarian tumors by color Doppler ultrasound,MSCT combined with serum HFA detection was significantly higher than that by single diagnosis.Conclusion The combined diagnosis of color Doppler ultrasound,MSCT,and serum HFA detection ca n significa ntly improve diagnostic sensitivity and accuracy.It can be used as an effective means to diagnose ovarian malignant tumors and provide a basis for clinical diagnosis and treatment.