奥氮平联合黛力新治疗女性神经性厌食症的疗效及其对内分泌功能的影响研究

Study on the efficacy of Olanzapine combined with Deanxit on female anorexia nervosa and its endocrine effect

目的分析奥氮平联合黛力新治疗女性神经性厌食症疗效及对内分泌的影响。方法选取2018年5月至2019年5月该院明确诊断的66例女性神经性厌食症患者,根据不同治疗方案将其分为对照组与观察组,对照组采用奥氮平治疗,观察组采用奥氮平联合黛力新治疗,对比两组临床疗效、内分泌功能[垂体-性腺轴激素:黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2);垂体-甲状腺轴激素:促甲状腺刺激激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)]、月经情况(闭经时间、月经恢复时间)、体重变化(体重、BMI)及不良反应评定[副反应量表(TESS)评分]。结果与对照组比较,观察组总有效率更高,治疗后垂体-性腺轴激素与垂体-甲状腺轴激素水平更优,月经恢复时间更短,体重与BMI更大,治疗2、4周TESS评分更低,差异有统计学意义(P<0.05)。结论奥氮平联合黛力新治疗女性神经性厌食症的疗效理想,可明显改善内分泌功能。

Objective To analyze the efficacy of Olanzapine combined with Deanxit on female anorexia nervosa and its endocrine effect.Methods A total of 66 female patients with anorexia nervosa diagnosed from May 2018 to May 2019 were selected and divided into the control group and the observation group with 33 cases in each group according to different treatment schemes.The control group was treated with Olanzapine,while the observation group was treated with Olanzapine combined with Deanxit.The clinical efficacy,endocrine function[pituitary-gonad axis hormone:luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E2);pituitary-thyroid axis hormone:thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)],menstrual status(amenorrhea time,menstrual recovery time),weight change(body weight,BMI),adverse reaction assessment(TESS score)were compared between the two groups.Results Compared with the control group,the observation group has a higher overall effective rate.the levels of pituitary-gonad axis hormone and pituitary-thyroid axis hormone were better after treatment,menstrual recovery time was shorter,body weight and BMI were greater,and TESS scores were higher at 2 and 4 weeks after treatment,the difference was statistically significant(P<0.05).Conclusion Olanzapine combined with Deanxit is effective in the treatment of female anorexia nervosa,which could significantly improve the endocrine function.