无过渡金属参与光催化1,2-氨基醇的绿色合成

Green Synthesis of 1,2-amino Alcohol Photocatalysis without Transition Metal

报道了一种可见光诱导下以非金属光敏剂4CzIPN为催化剂的氨基酸与羰基化合物的脱羧自由基偶联反应.该反应以乙腈为溶剂,以良好到优异的产率高效地获得了不同的1,2-氨基醇类化合物,具有反应条件绿色温和、原料廉价易得、反应适用范围广等优点,有一定的工业应用前景.

A visible-light-induced decarboxylation radical coupling reaction of amino acids and carbonyl compounds catalyzed by organic photosensitizer 4CzIPN was reported.Different kinds of 1,2-aminoalcohols were efficiently obtained in good to excellent yields by using acetonitrile as the solvent,which featured with green and mild reaction conditions,cheap raw materials,wide range of substrate scopes and potential industrial application prospect.