Gray Matter-Based Age Prediction Characterizes Different Regional Patterns

Dear Editor,The brain experiences ongoing changes across different ages to support brain development and functional reorganization.During the span of adulthood,although the brain has matured from a neurobiological perspective,it is still continuously shaped by external factors such as habits,the family setting,socioeconomic status,and the work environment [1].In contrast to chronological age (CA),brain(or biological) age (BA) is conceptualized as an important index for characterizing the aging process and neuropsychological state,as well as individual cognitiveperformance.Growing evidence indicates that BA can be assessed by neuroimaging techniques,including MRI [2].