早期CRRT干预对腹源性脓毒症患者免疫调节作用的研究

Effect of early CRRT intervention on immunoregulation in patients with abdominal sepsis

目的观察早期进行连续肾脏替代疗法(continuous renal replacement therapy,CRRT)干预对腹源性脓毒症患者免疫功能的影响。方法取我院ICU 2018年1月至2020年6月的AS患者60例,随机分两组,常规治疗按指南进行;治疗组AKI1级时进行CRRT干预,治疗最少3天,每天至少12小时。对照组则AKI2级或以上时CRRT,方案相同。记录干预前及干预后第7天的感染指标、免疫指标等。统计分析应用SPSS 24.0软件进行t检验。结果治疗组PCT、HLA-DR、CD4+/CD8+等均显著改善(P<0.01)。结论早期CRRT的干预能及时阻断免疫麻痹,减轻炎症反应,改善预后。

Objective:To observe the effect of early CRRT intervention on immune function in patients with abdominal sepsis.Methods:Sixty patients with abdominal sepsis in ICU of our hospital for two and a half years were randomly divided into two groups.The routine treatment was carried out according to the guidelines while the treatment group was given CRRT intervention at AKI level 1,at least 3 days,at least 12 hours a day.In the control group,CRRT was used when AKI was 2 or above.The infection index and immune index were recorded before and 7 days after the intervention.SPSS 24.0 software was used for t test.Results:PCT,HLA-DR,CD4+/CD8+were significantly improved in the treatment group(P<0.01).Conclusion:Early CRRT intervention can block immune paralysis,reduce inflammatory reaction and improve prognosis.