早发性脊柱侧凸肺发育与相关机械力的刺激

Pulmonary development and related mechanical stimulations of early-onset scoliosis

肺泡生长速度最快的时期是在2岁以前[1],2~4岁时,肺泡细胞数量达到成年人水平(3亿~6亿个),这之后肺泡的数量、大小和复杂程度可能还会继续缓慢增加,直至青春期甚至成年期[2-3]。越早发生在胸段的脊柱畸形,对胸廓的形态、活动度、容积影响就越大,同时产生的异常机械应力对肺细胞生长发育、组织分化的影响就越大。

Early-onset scoliosis (EOS) generally refers to scoliosis in children younger than 10 years old.Children with EOS are often accompanied with abnormal thoracic morphology and structure which restricts thoracic activity and leads to uncoordinated respiratory movement,resulting in abnormal mechanical stress in the process of proliferation and differentiation of lung cells to affect the growth of lung tissues and respiratory functions.It is particularly important to establish a reasonable in vitro culture model to analyze the impact of abnormal mechanical stress caused by EOS on lung growth and development.This paper summarizes principles and effects of several experimental methods simulating lung cell culture under various mechanical stresses in vitro to explore the application prospect.