年龄相关性白内障患者氧化损伤修复基因表观遗传学研究进展

Research progress of epigenetic modification changes of oxidative damage repair genes in patients with sage-related cataract

氧化损伤是目前较为公认的年龄相关性白内障(ARC)发病机制。晶状体上皮细胞的氧化损伤会引起DNA损伤,而DNA氧化损伤修复能力不足或不及时均会引起ARC的发生。近年来发现,许多眼睛疾患的发病机制受表观遗传、环境及遗传等因素的影响,并且表观遗传学通过调控DNA氧化损伤修复基因的表达在ARC发生机制中起重要作用。本文系统阐述了ARC中表观遗传学如何调控DNA氧化损伤修复基因,并结合本课题组的研究发现进一步探讨其研究价值。

Oxidative damage is the currently recognized pathogenesis of age-related cataract(ARC).Oxidative damage of lens epithelial cells(LECs)causes DNA damage.However,the insufficient or delayed repair ability of DNA oxidative damage will cause the occurrence of ARC.Recently,evidences have been found that the pathogenesis of many eye diseases is regulated by the interaction of epigenetic,environmental and genetic factors.The emergence of epigenetic studies indicates that DNA oxidative damage repair genes play an important role in the pathogenesis of ARC.This paper systematically reviews previous studies on the mechanism of epigenetics regulating DNA oxidative damage repair genes in ARC,and further explores the research value in combination with our own researches.