多发性成人型黄色肉芽肿

Multiple adult xanthogranuloma: a case report

报告1例多发性成人型黄色肉芽肿。患者男,61岁。面部丘疹1年。皮肤科检查:面部见多个淡黄色半球形光滑丘疹,部分丘疹表面见毛细血管扩张。皮肤镜检查:见橘黄色云状无结构区域,周边见纤细的红色边缘。皮损组织病理检查:表皮大致正常;真皮内见境界清楚的细胞团块,主要由组织细胞及少量炎性细胞组成,组织细胞泡沫化,可见Touton巨细胞。免疫组化染色示CD68阳性,S-100蛋白阴性,CD1a阴性。最终诊断为多发性成人型黄色肉芽肿。

A case of multiple adult xanthogranuloma is reported. A 61-year-old male presented with papules on face for 1 year.Physical examination revealed multiple hemispheroid yellow-colored papules, some of which show telangiectasias, on his face. Dermoscopy revealed "clouds" of orange area, with thin red border. Histopathologic examination showed normal epidermis and a wellcircumscribed cellular aggregate in the dermis. The dermal infiltrates were composed of histiocytes mixed with a few inflammatory cells. The histiocytes had foamy cytoplasm. Touton giant cells were noted. Immunohistochemistry showed that the dermal infiltrates were positive for CD 68, and were negative for S100 and CD1a. A diagnosis of multiple adult xanthogranuloma was made.