基于数据挖掘分析《中国百年百名中医临床家丛书》中关节痹痛的用药规律

Analysis on the medication rules of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series based on data mining

目的运用数据挖掘技术分析《中国百年百名中医临床家丛书》治疗关节痹痛的用药规律。方法收集《中国百年百名中医临床家丛书》中治疗关节痹痛的处方并建立数据库,采用“中医传承辅助平台(V2.5)”软件集成的规则分析、复杂系统熵层次聚类等数据挖掘方法对处方进行分析。结果对筛选的393首处方进行分析,得出近现代百名中医大家治疗关节痹痛的常用药物有当归、桂枝、牛膝、白芍、甘草、威灵仙、黄芪、秦艽、桑寄生、防己,处方药物味多为苦、甘、辛,性温,归肝、脾、肾经。高频药物组合(药对)包括黄芪-当归、当归-桂枝、当归-白芍、白芍-桂枝、甘草-桂枝、黄芪-桂枝、牛膝-当归、川芎-当归、威灵仙-桑寄生、鸡血藤-当归等。新处方包括熟地黄-爵床、厚朴-淡竹叶、牛蒡子-白芍、茜草-杏仁、木通-鹿茸等。结论以中医传承辅助平台为基础,利用数据挖掘技术发现,近现代百名中医大家治疗关节痹痛遵循“寒者热之”“虚者补之”“实者泻之”的治疗法则,体现了从正气不足,风、寒、湿三气夹杂来诊治关节痹痛的学术思想,符合中医标本兼治的用药原则。

Objective To analyze the medication rules of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series by data mining technology.Methods The prescriptions for the treatment of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series were collected and established a database.The prescriptions were analyzed by using the integration rules and complex system entropy hierarchical clustering and other data analysis methods of“traditional Chinese medicine inheritance support system(V2.5)”.Results The analysis of the 393 screened prescriptions showed that the common drugs used by hundreds of TCM doctors in modern times to treat arthralgia are Radix Angelicae Sinensis,Ramulus Cinnamomi,Radix Achyranthis Bidentatae,Radix Paeoniae Alba,Radix Glycyrrhizae,Radix Clematidis,Radix Astragali seu Hedysari,Radix Gentianae Macrophyllae,Herba Taxilli,Radix Stephaniae Tetrandrae.The flavours of drugs in prescriptions mostly are bitter,sweet and pungent,the nature is warm,and the drugs of prescriptions mostly belong to the liver,spleen and kidney meridians.High-frequency drug combinations(medicine pairs)include Radix Astragali seu Hedysari-Radix Angelicae Sinensis,Radix Angelicae Sinensis-Ramulus Cinnamomi,Radix Angelicae Sinensis-Radix Paeoniae Alba,Radix Paeoniae Alba-Ramulus Cinnamomi,Radix Glycyrrhizae-Ramulus Cinnamomi,Radix Astragali seu Hedysari-Ramulus Cinnamomi,Radix Achyranthis Bidentatae-Radix Angelicae Sinensis,Rhizoma Ligustici Chuanxiong-Radix Angelicae Sinensis,Radix Clematidis-Herba Taxilli,Caulis Spatholobi-Radix Angelicae Sinensis,etc.New prescriptions include Radix Rehmanniae Preparata-Rostellularia procumbens(L.)Ness,Cortex Magnoliae Officinalis-Herba Lophatheri,Fructus Arctii-Radix Paeoniae Alba,Radix Rubiae-Semen Armeniacae Amarum,Caulis Akebiae-Cornu Cervi Pantotrichum,etc.Conclusion Based on traditional Chinese medicine inheritance support system and using data mining technology,it is found that most of hundreds modern Chinese medicine practitioners treat arthralgia follow the therapeutic principle of“treating cold syndrome with heat methods”,“treating deficiency syndrome with tonifying methods”,“treating excess syndrome with purgative methods”,it reflects the academic idea of treating arthralgia from insufficiency of vital qi and the mixture causes of wind,cold and dampness,and it conforms to the principle of TCM treating both manifestation and root cause of disease.