自拟补肾化痰方联合二甲双胍对多囊卵巢综合征胰岛素抵抗及氧化应激的影响

Effect of self-made Bushen Huatan Decoction combined with Metformin on insulin resistance and oxidative stress in polycystic ovary syndrome

目的探讨自拟补肾化痰方联合二甲双胍对多囊卵巢综合征(PCOS)胰岛素抵抗及氧化应激的影响。方法选取2018年6月—2019年6月江苏省泰州市姜堰中医院收治的70例PCOS胰岛素抵抗患者,按随机数字表法将其分为对照组及观察组,各35例。对照组给予二甲双胍治疗,观察组在对照组的基础上予以自拟补肾化痰方治疗,疗程为3个月。观察两组临床疗效和治疗前后中医证候积分、体重指数、激素水平及不良反应情况。结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组体重指数、促黄体生成素(LH)/促卵泡刺激素(FSH)、空腹血糖(FBG)、胰岛素抵抗指数(HOMA-IR)均低于治疗前,谷胱甘肽过氧化物酶(GSH-Px)高于治疗前,且观察组体重指数、LH/FSH、FBG、HOMA-IR低于对照组,GSH-Px高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论自拟补肾化痰方联合二甲双胍治疗PCOS胰岛素抵抗的效果显著,安全性高,且改善氧化应激及雌激素水平。

Objective To explore the effect of self-made Bushen Huatan Decoction combined with Metformin on insulin resistance and oxidative stress in polycystic ovary syndrome(PCOS).Methods From June 2018 to June 2019,70 patients with PCOS insulin resistance in Jiangyan Hospital of Traditional Chinese Medicine of Taizhou City in Jiangsu Province were selected and divided into control group and observation group according to random number table method,with 35 cases in each group.Control group was treated with Metformin,and observation group was treated with self-made Bushen Huatan Decoction on the basis of control group.The course of treatment was three months.Clinical efficacy,traditional Chinese medicine syndrome score,body mass index,hormone level before and after treatment and adverse reaction of two groups were observed.Results Total effective rate of observation group was higher than that of control group(P<0.05).After treatment,traditional Chinese medicine syndrome scores of two groups were lower than those before treatment,and observation group was lower than that control group,the differences were statistically significant(P<0.05).After treatment,body mass index,luteinizing hormone(LH)/follicle stimulating hormone(FSH),fasting blood glucose(FBG)and insulin resistance index(HOMA-IR)of two groups were lower than those before treatment,and glutathione peroxidase(GSH-Px)of two groups was higher than that before treatment,body mass index,LH/FSH,FBG and HOMA-IR of observation group were lower than those of control group,and GSH-Px of observation group was higher than that of control group,the differences were statistically significant(P<0.05).There was no significant difference in incidence of adverse reactions between two groups(P>0.05).Conclusion Self-made Bushen Huatan Decoction combined with Metformin has significant effect on PCOS insulin resistance,it has high safety and can improve oxidative stress and estrogen levels.