基于数据挖掘分析郑惠芳教授治疗崩漏的组方规律

Prescription rules analysis of Professor Zheng Huifang in treating metrorrhagia based on data mining

目的通过数据挖掘,探讨全国名老中医郑惠芳教授治疗崩漏的组方及用药规律。方法收集郑惠芳教授在以往临床教学及科研中所发表的论文、著作、病历记录中诊断为崩漏的患者处方,并将符合标准的数据录入中医传承辅助平台软件,利用该平台建立相应数据库,并对数据进行统计与分析。结果收集郑惠芳教授符合标准的病案共计63例,处方共有271首,由分析可知,高频药物为熟地黄、黄芪、甘草、龙骨、白术、阿胶、五味子、墨旱莲、山茱萸、白芍。按照中药功效进行分类,多见补气药、补阴药、补血药、收涩药。通过对中药四气五味进行分析,用药以温、平性药,甘、苦、辛味药多见;通过对用药归经进行分析,治疗上多为肝经药,肾、脾经药次之。通过聚类得出3个新方组合分别是牡蛎,龙骨,当归,茯苓,升麻;山茱萸,山药,熟地黄,三七;杜仲,阿胶,白术,荆芥穗炭,薏苡仁。结论通过数据挖掘发现,郑惠芳教授治疗崩漏多以补脾益肾及养肝等治法,在用药方面,多擅长应用甘温性药物。通过分析得到的新处方需临床医生进一步验证其合理性。通过分析也为临床中更好地应用中药治疗崩漏提供了方向。

Objective To explore the prescription and medication rules of Professor Zheng Huifang of national famous veteran Chinese medicine practitioners in the treatment of metrorrhagia through data mining.Methods The prescriptions of metrorrhagia diagnosed by Professor Zheng Huifang in the papers,books and medical records published in the past clinical teaching and scientific research were collected.And the standard data was entered into the traditional Chinese medicine inheritance support system,the corresponding database was established by using the platform,and the data was counted and analyzed.Results A total of 63 medical records of Professor Zheng Huifang were collected,including 271 prescriptions.According to the analysis,the high-frequency drugs were Radix Rehmannia Preparata,Radix Astragali seu Hedysari,liquorice root,Os Draconis,Rhizoma Atractylodis Macrocephala,ass hide glue,Fructus Schisandrae Chinensis,Herba Ecliptae,Fructus Corni and Radix Paeoniae Alba.According to the efficacy of traditional Chinese medicine,qi tonic,yin tonic,blood tonic and astringent drugs were more common.Through the analysis of the four qi and five flavors of traditional Chinese medicine,the drugs used were warm,mild,sweet,bitter and pungent.According to the analysis of the meridian tropism of drugs,the drugs of liver meridian were the most commonly used,followed by the drugs of kidney and spleen meridians.Through cluster analysis,three new combinations were obtained:Oyster shall,Os Draconis,Radix Angelicae Sinensis,Poria,Rhizoma Cimicifugae;Cornus officinalis,Rhizoma Dioscoreae,Radix Rehmanniae Preparata,sanqi;eucommia,ass hide glue,Rhizoma Atractylodis macrocephala,Schizonepeta tenuifolia,coix seed.Conclusion Through data mining,Professor Zheng Huifang in the treatment of metrorrhagia is mainly based on nourishing the spleen,kidney and liver,pay attention to the sweet and warm drugs in medication.The new prescription obtained through analysis needs to be further verified by clinicians.Through the analysis,it also provides the direction for the better application of traditional Chinese medicine in the clinical treatment of metrorrhagia.