胃肠道神经内分泌肿瘤的核医学诊治进展

Advances in the Nuclear Medicine:Diagnosis and Management of gastrointestinal neuroendocrine tumors

生长抑素受体在胃肠道神经内分泌肿瘤中高表达,是胃肠道神经内分泌肿瘤的特异性受体。因此,通过放射性核素标记的生长抑素类似物可以实现对胃肠道神经内分泌肿瘤的精准成像和靶向治疗。随着生长抑素类似物和放射性核素的不断开发,基于生长抑素受体的核医学成像和肽受体放射性核素治疗已成为胃肠道胰腺神经内分泌肿瘤诊断和治疗的新热点。

The somatostatin receptor(SSTR)is a targetable receptor frequently expressed in the gastroenteropancreatic neuroendocrine tumors(GEP-NETs).Therefore,SSTR becomes a promising target for tumor-targeted therapies and radiography by radionuclide peptide receptor.With the fast development of somatostatin analogue and radionuclide,SSTR-based somatostatin receptor imaging and peptide receptor radionuclide therapy has become a new hot topic in diagnosing and treating GEP-NETs.