血脂水平与脑卒中后情感失禁关系的临床研究

Relationship between lipid levels and post-stroke emotional incontinence

目的探讨缺血性卒中患者的血脂水平与卒中后情感失禁(PSEI)之间的关系。方法收集2018年7月至2019年6月于辽阳市中心医院神经内科住院的急性缺血性卒中患者为研究对象,次晨完善餐前血脂检查,包括总胆固醇(TC)、血清甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。依据House标准和病理性哭笑量表(PLACS)评分结果,将入组患者分为PSEI组(研究组)及非PSEI组(对照组),分析血脂水平与PSEI之间的关系。结果性别是PSEI发生的独立危险因素(O^R=2.019,P=0.003),女性更易患PSEI;TC水平增高是PSEI发生的保护因素(O^R=0.732,P=0.006),即TC水平降低为PSEI发生的独立危险因素。LDL-C(r=0.202,P=0.048)与PSEI病情严重程度呈正相关,TC、TG和HDL-C与PSEI病情严重程度无明显相关性(P>0.05)。结论TC与PSEI的发生相关,其水平降低是PSEI发生的独立危险因素。LDL-C水平与PSEI病情严重程度呈正相关,LDL-C水平越高,PSEI患者的情感失禁程度越重。

【Objective】To explore the relationship between the blood lipid levels and post-stroke emotional incontinence(PSEI)after ischemic stroke.【Methods】Patients with acute ischemic stroke who were admitted to the department of neurology of Liaoyang Central Hospital from July 2018 to June 2019 were selected to complete fasting lipid tests including total cholesterol(TC),triacylglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C).Patients were divided into PSEI group(study group)and non-PSEI group(control group)according to the House standard and the results of Pathological Laughter and Crying Scale(PLACS),and then the blood lipid levels and PSEI were analyzed.【Results】Gender was an independent risk factor for the occurrence of PSEI(OR=2.019,P=0.003),women were more likely to get PSEI;the increase level of TC was protective factor for the occurrence of PSEI(OR=0.732,P=0.006),and the decrease level of TC was an independent risk factor for the occurrence of PSEI.LDL-C(r=0.202,P=0.048)was positively correlated with the severity of PSEI,while TC,TG,and HDL-C were not significantly correlated with the severity of PSEI(P>0.05).【Conclusion】TC is related to the occurrence of PSEI,and its decrease may be an independent risk factor for PSEI.The level of LDL-C is positively related to the severity of PSEI.The higher the level of LDL-C,the more severe the emotional incontinence in patients with PSEI.