FeCl3催化硫醇与亚胺离子的亲核反应

FeCl_(3)-catalyzed nucleophilic reaction of acyliminium ions with thioalcohols

以γ-羟基内酰胺和硫醇为原料,1,2-二氯乙烷为溶剂,在三氯化铁促催化下生成亚胺离子,而后硫醇发生亲核反应构建3-硫醚基异吲哚啉酮类化合物。该反应70℃条件下搅拌6 h即可完成,产率87~94%,该反应底物适用范围广,对于不同的γ-羟基内酰胺类化合物以及不同的伯硫醇和仲硫醇,反应均可以顺利得到相应的产物。

An effcient FeCl_(3)-promoted nucleophilic reaction of acyliminium ions withγ-hydroxy lactams and thioalcohols for the synthesis of 3-sulfenylated isoindolinones had been developed.The reaction could be acchieved at 70 o C for 6 h and the yield was 87~94%.The prominent features of the present strategy were wide substrate scope and excellent group tolerability.