单纯放疗与同步放化疗治疗非早期宫颈癌患者的效果及对细胞免疫功能的影响

Effect of radiotherapy alone and concurrent chemoradiotherapy in the treatment of patients with non early cervical cancer and its influence on cellular immune function

目的分析单纯放疗与同步放化疗治疗非早期宫颈癌患者的效果及对细胞免疫功能的影响。方法将100例非早期宫颈癌患者根据随机数字表法分为对照组(45例,单纯放疗)与试验组(55例,同步放化疗)。比较两组的免疫功能指标、临床疗效及不良反应发生情况。结果治疗后,两组的NK细胞水平高于治疗前,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均低于治疗前(P<0.05)。试验组的治疗总有效率为76.36%,显著高于对照组的48.89%(P<0.05)。试验组的Ⅲ~Ⅳ度骨髓抑制、消化道反应发生率均高于对照组(P<0.05)。结论同步放化疗治疗非早期宫颈癌患者能够有效缓解临床症状,对免疫功能改善较小,不良症状可耐受。

Objective To analyze the effect of radiotherapy alone and concurrent chemoradiotherapy in the treatment of patients with non early cervical cancer and its influence on cellular immune function.Methods A total of 100 patients with non early cervical cancer were divided into control group(45 cases,radiotherapy alone)and experimental group(55 cases,concurrent chemoradiotherapy)by the random number table method.The immune function indexes,clinical efficacy and adverse reactions of the two groups were compared.Results After treatment,NK cell level in the two groups was higher than that before treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were lower than those before treatment(P<0.05).The total effective rate of treatment in the experimental group was 76.36%,which was significantly higher than 48.89%in the control group(P<0.05).The incidences of gradeⅢ-Ⅳof myelosuppression and digestive tract reaction in the experimental group were higher than those in the control group(P<0.05).Conclusion Concurrent chemoradiotherapy in the treatment of non early cervical cancer patients can effectively alleviate the clinical symptoms,improve the immune function slightly,and the adverse symptoms can be tolerated.