丁苯酞、尼莫地平分别联合艾地苯醌治疗血管性痴呆的对比研究

A Comparative Study of Butylphthalide Combined with Idebenone Vs.Nimodipine Combined with Idebenone in the Treatment of Vascular Dementia

目的探讨丁苯酞、尼莫地平分别联合艾地苯醌治疗血管性痴呆的临床效果。方法选取2017年12月至2019年12月我院收治的76例血管性痴呆患者,随机分为两组各38例。A组采用丁苯酞联合艾地苯醌治疗,B组采用尼莫地平联合艾地苯醌治疗,比较两组的治疗效果。结果治疗前,两组的MMSE、MoCA及ADL评分比较,差异无统计学意义(P>0.05);治疗后,A组的MMSE、MoCA及ADL评分均显著高于B组(P<0.05)。治疗期间,A组的不良反应发生率为7.89%,显著低于B组的28.95%(P<0.05)。结论丁苯酞联合艾地苯醌治疗血管性痴呆患者的临床效果较尼莫地平联合艾地苯醌更好,可有效改善患者的精神、认知及日常活动能力,且安全性较高。

Objective To explore the effects of butylphthalide combined with idebenone vs.nimodipine combined with idebenone in the treatment of vascular dementia.Methods 76 patients with vascular dementia admitted to our hospital from December 2017 to December2019 were selected and randomly divided into two groups,with 38 patients in each group.Group A was treated with butylphthalide combined with idebenone,and group B was treated with nimodipine combined with idebenone.The therapeutic effects of two groups were compared.Results Before treatment,no significant difference was found in MMSE,MoCA and ADL scores between two groups(P>0.05);After treatment,the MMSE,MoCA and ADL scores of group A were significantly higher than those of group B(P<0.05).During treatment,the incidence of adverse reactions of group A was 7.89%,significantly lower than 28.95%of group B(P<0.05).Conclusions Butylphthalide combined with idebenone has better clinical effect than nimodipine combined with idebenone in the treatment of patients with vascular dementia,which can effectively improve patients’mentality,cognition and daily activity ability,and has high safety.