硫酸酯酶2与肝细胞癌关系的研究进展

Research advances in SULF2 and its relationship with hepatocellular carcinoma

细胞分泌的硫酸酯酶2是一种内源性硫酸酯酶,可水解细胞外基质中或细胞膜外表面硫酸乙酰肝素链上的硫酸基团,可使结合在硫酸乙酰肝素蛋白聚糖上的生长因子解离,提高局部生长因子浓度,激活下游信号。硫酸酯酶2在多种肿瘤中高表达,在肝细胞癌中硫酸酯酶2表达升高与不良预后有关。硫酸酯酶2可通过激活肝癌细胞内多条信号通路促进肿瘤进展。抑制肝癌细胞硫酸酯酶2的活性,可抑制肝癌细胞的增殖、迁移及成瘤能力。本文就硫酸酯酶2与肝细胞癌关系的研究进展进行综述。

Cell secreted sulfatase 2 is an endogenous sulphate esterase,which can hydrolyze the sulphate groups in extracellular matrix or on the chain of heparan sulphate on the outer surface of cell membrane,which can dissociate the growth factor bound to heparan sulphate proteoglycan,improve the local concentration of growth factor and activate the downstream signal.Sulfatase 2 is highly expressed in a variety of tumors,and the increased expression of sulfatase 2 in hepatocellular carcinoma is associated with poor prognosis.Sulfatase 2 can promote tumor progression by activating multiple signaling pathways in hepatocellular carcinoma cells.Inhibit the activity of hepatocellular carcinoma cell sulfatase 2,and then inhibit the proliferation,migration and tumorigenesis of hepatocellular carcinoma cells.In this paper,the research progress of sulfatase 2 and its role in the occurrence and development of hepatocellular carcinoma is summarized.