柑橘多甲氧基黄酮饼干对高血脂症小鼠的降脂效应

Lipid-lowering effect of citrus polymethoxyflavonoid cookies on hyperlipidemia mice

目的本研究为首次在高脂血症小鼠模型中,通过脂代谢实验指标的测量,评价将柑橘多甲氧基黄酮粉末加入饼干后的降脂作用,旨在为开发一种新型功能食品提供依据。方法将60只雄性KM小鼠随机分为6组,连续喂养6周,建立高脂小鼠模型,而后饲喂相应饼干,继续喂养6周后,检测小鼠体重、Lee’s指数、脏器变化、肝组织生化指标和血清中血脂含量的变化。结果6周后,小鼠体重、Lee’s指数、脏器变化、肝组织生化指标和血清中血脂含量均表明多甲氧基黄酮饼干能抑制高血脂小鼠体重的增长,降低高血脂小鼠的Lee’s指数,改善高血脂模型小鼠血清中常见生化指标的脂质代谢异常。结论多甲氧基黄酮饼干能明显改善高血脂模型小鼠血清中常见生化指标的脂代谢异常。降脂饼干对小鼠血脂影响方面:降脂饼干对甘油三酯(TG)的影响明显,对高密度脂蛋白(HDL-C)没有明显影响,对低密度脂蛋白(LDL-C)影响也较为明显。揭示了其或可发挥对血脂异常及由血脂异常造成的脂肪肝等相关疾病的治疗或保健作用。

Objective This study evaluated the lipid-lowering effect of adding citrus polymethoxyflavonoid powder to biscuits through measurement of lipid metabolism indicators in a hyperlipidemia mouse model to develop a new type functional food.Methods Sixty male KM mice were randomly divided into six groups and fed for 6 weeks to establish a high fat mouse model.Then,they were fed with the corresponding biscuits.After 6 weeks of feeding,the weight,Lee’s index,serum lipid levels,and indexes of the liver,spleen,heart,and kidney were assessed.Results After 6 weeks,polymethoxyflavonoid biscuits inhibited the weight increase of hyperlipidemia mice and reduced hyperlipidemia.Polymethoxyflavonoid biscuits significantly improved abnormal lipid metabolism of common biochemical indicators in the serum of hyperlipidemia model mice.In terms of the effect of lipid-lowering biscuits on blood lipids in mice,the lipidlowering biscuits had a significant effect on triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C),but had no obvious effect on high-density lipoprotein cholesterol(HDL-C).Conclusions Citrus polymethoxyflavonoid powder may be a therapeutic agent for dyslipidemia,fatty liver,and other related diseases.