浆细胞性乳腺炎动物模型制备及模型效果评价的研究进展

Research progress of animal model preparation and effect evaluation of plasma cell mastitis

浆细胞性乳腺炎(plasma cell mastitis,PCM)为较常见乳腺疾病,国内发病率与日俱增。PCM主要发生于非哺乳期中年女性,其临床表现及病理改变复杂,治疗手段亦多样化。目前PCM主要集中于临床观察研究,病理过程、发病机制尚不完全明确,基础研究严重不足,因此制备PCM动物模型并进行有效的评估对深入研究分子机制、评估治疗手段具有重要的意义。本文以PCM动物模型种类、动物模型制备方法、模型病理及影像效果评价等方面为切入点进行综述,以期为后续的研究奠定理论基础。

Plasma cell mastitis(PCM)is a common breast disease,with an incidence rate that continues to increase.The main pathological changes of PCM were in middle-aged non lactation women.The clinical manifestations and pathological changes of PCM are complex,and the treatment method are also diverse.At present,most studies on PCM mainly focus on clinical observation and research;however,the pathological process and pathogenesis are not completely clear,and basic research in PCM is insufficient.Therefore,the preparation of animal models of PCM is of great significance for study of the molecular mechanism and evaluation of therapeutic method for PCM.In this paper,PCM animal model types,animal model preparation method,model pathology and result were reviewed.This review will help lay a theoretical foundation for follow-up research for PCM.