基于GelMA复合水凝胶的制备及性能研究

Preparation and Properties of GelMA Composite Hydrogel

水凝胶是一种非常重要的材料,可直接用于组织工程中.但由于其机械性能较差,该研究选择了左旋聚乳酸(PLLA)和功能化明胶作为复合材料.首先将明胶与甲基丙烯酸酐(Methacrylic Anhydride,MA)通过化学反应合成具有光敏性的甲基丙烯酰胺基明胶(Gelatin Methacrylate,GelMA),并将其与左旋聚乳酸(PLLA)按不同比例共混,通过紫外光照成形的方法制备复合型水凝胶.对复合水凝胶进行相关表征,如热重分析(TG)、差示扫描热分析(DSC)、X射线衍射(XRD)和扫描电镜(SEM)等,检测了解其热力学性质、结晶态、形貌等特征,根据结果选择最适合的配比方案.

Hydrogel is a very important material and can be used directly in tissue engineering. However,due to its poor mechanical properties,poly(L-lactide)(PLLA)and functional gelatin were chosen as composite materials in this study. First,photosensitive gelatine methacrylamide(GelMA)was synthesized by chemical reaction using gelatin and methacrylic anhydride(MA). Then the composite hydrogel was prepared under UV light exposure at different ratio. The properties of thermodynamics,degree of crystallinity and morphology,were tested by Thermogravimetric Analysis(TG),Differential Scanning Calorimetry(DSC),X-ray Diffraction(XRD)and Scanning Electronic Microscopy. And(SEM)a scheme of material concentration ratio which is most suitable for composite hydrogel was selected.