上海市崇明区老年人成纤维活化蛋白与代谢综合征的相关性分析

Correlation analysis of fibroblast activation protein and metabolic syndrome in the elderly in Chongming District of Shanghai City

目的探讨老年人血浆成纤维活化蛋白(FAP)水平与代谢综合征的相关性。方法2011年6月—12月,采取随机整群抽样的方法,以上海市崇明区城桥镇587例常住居民为研究对象,其中男性202例、女性385例。通过问卷调查和体格检查采集人体基本参数,采集标本完成相关实验室检查,分析FAP水平与代谢综合征的相关性。结果男性血浆FAP水平与年龄、心率、身体质量指数(BMI)、高密度脂蛋白胆固醇(HDL-C)、HDL-C/总胆固醇(TC)、胰岛素水平、稳态模型评估胰岛素抵抗指数、稳态模型评估胰岛β细胞功能及估计肾小球滤过率(eGFR)相关(均P<0.05)。女性血浆FAP水平与心率、HDL-C、三酰甘油、HDL-C/TC、空腹血糖、餐后2h血糖(2hPG)相关(均P<0.05)。Stepwise线性回归模型显示,年龄、心率、胰岛素和eGFR是男性血浆FAP水平的独立影响因素,而心率、2 hPG和HDL-C/TC是女性血浆FAP水平的独立影响因素。二元Logistic回归分析显示,女性血浆FAP水平Q4组代谢综合征发生风险较Q1组增加(OR=2.28,95%CI:1.27~4.10,P<0.01),校正其他危险因素后仍然存在相关性(OR=1.93,95%CI:1.01~3.67,P<0.05)。结论血浆FAP水平与糖脂代谢指标有一定的相关性,FAP可能是老年女性代谢综合征发病风险中的一个独立危险因素。

Objective To investigate the relationship between the level of plasma fibroblast activation protein(FAP)and metabolic syndrome in the elderly.Methods From June to December 2011,587 permanent residents in Chengqiao Town of Chongming District of Shanghai City were selected by random cluster sampling method,including 202 males and 385 females.The basic parameters of human body were collected through questionnaire survey and physical examination,and the samples were collected to complete the relevant laboratory examination.The correlation between FAP level and metabolic syndrome was analyzed.Results Plasma FAP level was correlated with age,heart rate,body mass index(BMI),high density lipoprotein cholesterol(HDL-C),HDL-C/total cholesterol(TC),insulin level,HOMA-IR,HOMA-βand estimated glomerular filtration rate(eGFR)in men(all P<0.05),and correlated with heart rate,HDL-C,triglyceride,HDL-C/TC,fasting blood glucose and 2 h postprandial blood glucose(2 hPG)in women(all P<0.05).Stepwise linear regression model showed that age,heart rate,insulin and eGFR were independent influencing factors of plasma FAP level in men,while heart rate,2 hPG and HDL-C/TC were independent influencing factors of plasma FAP level in women.Binary logistic regression model showed that plasma FAP level was associated with metabolic syndrome in female Q4 group(OR=2.28,95%CI:1.27-4.10,P<0.01),and there was still correlation after adjusting for other risk factors(OR=1.93,95%CI:1.01-3.67,P<0.05).Conclusion There is a certain correlation between plasma FAP level and glucose and lipid metabolism indexes.FAP may be an independent risk factor of metabolic syndrome in elderly women.