Glutamine metabolism in Th17/Treg cell fate:applications in Th17 cell-associated diseases

Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies.Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells.Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate.Some examples of a glutamine metabolism-dependent modulation of the development and progression of several Th17/Treg cell-associated diseases are provided afterward.This review will provide a comprehensive understanding of the importance of glutamine metabolism in the fate of Th17/Treg cell differentiation.