摘要
目的:观察乌头汤治疗肾虚督寒型强直性脊柱炎的临床疗效。方法:将60例活动期肾虚督寒型强直性脊柱炎患者随机分为治疗组和对照组,每组30例。治疗组口服乌头汤治疗,对照组口服美洛昔康片治疗。2组均以4周为1个疗程。观察2组ASAS20疗效、ASAS40疗效、中医证候疗效,以及治疗前后脊柱痛视觉模拟评分法(VAS)评分、患者自我评价VAS评分、Bath强直性脊柱炎功能指数(BASFI)、Bath强直性脊柱炎活动指数(BASDAI)、中医证候积分等指标,并评估安全性。结果:治疗组ASAS40达标率为33.33%,明显优于对照组的6.67%,2组比较,差异有统计学意义(P<0.05)。2组中医疗效总有效率均为83.33%,差异无统计学意义(P>0.05)。治疗后,2组脊柱痛VAS评分、患者自我评价VAS评分、BASFI、BASDAI较治疗前均有一定改善,差异有统计学意义(P<0.05);2组间各指标比较,差异无统计学意义(P>0.05)。结论:乌头汤对肾虚督寒型强直性脊柱炎的临床疗效较好,且安全性高。
Objective:To observe the clinical effect of Wutou Tang(乌头汤)on ankylosing spondylitis of kidney deficiency and Du Meridian cold type.Methods:Sixty cases of active ankylosing spondylitis of kidney deficiency and Du Meridian cold type were randomly divided into a treatment group and a control group,30 cases in each group.The treatment group was treated with Wutou Tang,while the control group was treated with meloxicam tablets.Both groups were treated for 4 weeks as a course.The efficacy of ASAS20 and ASAS40,TCM syndrome efficacy,and evaluate the security,visual analogue scale(VAS)score of spinal pain,VAS score of patients'self-evaluation,Bath Ankylosing Spondylitis Functional Index(BASFI),Bath Ankylosing Spondylitis Activity Index(BASDAI),TCM syndrome score and other indicators were observed before and after treatment in the two groups.Results:The compliance rate of ASAS40 in the treatment group was 33.33%,which was significantly better than 6.67%in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the two groups was 83.33%,and the difference was not statistically significant(P>0.05).After treatment,the VAS,VAS score of spinal pain,VAS score of patients'self-evaluation,BASDAI and BASFI of the two groups were improved compared with those before treatment,and the difference was statistically significant(P<0.05),but there was no significant difference between the two groups(P>0.05).Conclusion:Wutou Tang is effective and safe in treating ankylosing spondylitis of kidney deficiency and Du Meridian cold type.
作者
程青青
李炜
程鹏
刘兆宜
汪荣盛
沈逸
秦盈盈
唐小蓉
沈杰
朱琦
何东仪
姜婷
CHENG Qing-qing;LI Wei;CHENG Peng;LIU Zhao-yi;WANG Rong-sheng;SHEN Yi;QIN Ying-ying;TANGXiao-rong;SHEN Jie;ZHU Qi;HE Dong-yi;JIANG Ting
出处
《风湿病与关节炎》
2021年第2期5-7,27,共4页
Rheumatism and Arthritis
基金
上海市卫计委基金项目(201640121)
上海市中西医临床协作试点项目[ZY(2018-2020)-FWTX-1010]
上海市中医专科联盟建设项目[ZY(2018-2020)-FWTX-4017]。
关键词
脊柱炎
强直性
肾虚督寒证
乌头汤
美洛昔康
临床疗效
spondylitis,ankylosing
kidney deficiency and Du Meridian syndrome
Wutou Tang(乌头汤)
meloxicam
clinical efficacy