摘要
纳米酶作为一种具有类酶活性的纳米材料,与天然酶相比,具有制备过程简单、受外界环境干扰小、对酸碱和温度具有较好的耐受性等优点.金属有机框架(metal-organic frameworks,MOFs),即多孔配位聚合物,具有结构多样性、高比表面积、孔隙率可控等独特性质.因有序框架的保护以及结构可调控的性质,基于MOFs构建的纳米酶受到研究人员的广泛关注.本文综述不同类型MOFs基的纳米酶,主要从原始MOFs、化学修饰的MOFs、MOFs基复合材料和MOFs衍生物等四大方面进行论述;随后,对4种类型MOFs基纳米酶的构建特点和生化分析应用进行归纳和比较;最后对其当前面临的挑战和未来的发展趋势进行讨论.
A kind of nanomaterials with enzyme-mimicking catalytic activity,named as nanozymes,have attracted the attention of researchers.Compared with natural enzymes,nanozymes exhibit the advantages of simple production,low cost and good stability.As a new class of porous coordination polymers,metal-organic frameworks(MOFs)possess many attractive properties,such as structural diversity,pore size tailorability,high specific surface area,and controllable porosity.MOFs-based nanozymes are attracting growing attention because of protection of the ordered framework and the adjustable structure.In this review,we summarize the construction of different types of MOFs-based nanozymes,including pristine MOFs,MOFs with modification,MOF-based composites,and MOF derivatives.Then,the typical applications of MOF-based nanozymes in the detection of various analytes are reviewed.We also summarized and compared the characteristic of MOFs-based nanozymes in different construction types.Finally,the current challenges and future developments of MOFs-based nanozyme are also discussed.
作者
陈思怡
陈垦
由天辉
孙端平
CHEN Si-Yi;CHEN Ken;YOU Tian-Hui;SUN Duan-Ping(School of Nursing,Guangdong Pharmaceutical University,Guangzhou 510310,China;School of Integrative Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China;Center for Drug Research and Development,Guangdong Pharmaceutical University,Guanghou 510006,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2021年第1期6-23,共18页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(82003710)资助项目.
关键词
金属有机框架
纳米酶
复合材料
生化分析
metal-organic frameworks
nanozymes
composite material
biochemical analysis