依达拉奉联合银杏达莫注射液治疗急性脑梗死患者的效果

Effects of Edaravone combined with Ginkgo leaf extract dipyridamole injection onacute cerebral infarction

目的:探讨依达拉奉联合银杏达莫注射液治疗急性脑梗死患者的效果。方法:选取80例急性脑梗死患者为研究对象,按照住院号奇偶分成对照组(n=40)和研究组(n=40)。两组均给予溶栓、抗血小板聚集、预防脑水肿等常规治疗,在此基础上对照组给予银杏达莫注射液治疗,研究组在对照组基础上联合依达拉奉注射液治疗。比较两组的临床疗效,治疗前后的血浆同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平,美国国立卫生院卒中量表(NIHSS)评分、格拉斯哥预后评分(GOS)、日常生活活动能力量表(ADL)评分,以及不良反应发生率。结果:治疗后,研究组治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05);研究组Hcy、hs-CRP水平均明显低于对照组,差异有统计学意义(P<0.05);研究组NIHSS评分低于对照组,GOS、ADL评分均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:依达拉奉联合银杏达莫注射液治疗急性脑梗死效果可靠,能够减轻炎症反应,改善神经功能缺损症状,具有较高的安全性。

Objective:To explore effects of Edaravone combined with Ginkgo leaf extract dipyridamole injection on acute cerebral infarction.Methods:80 patients with acute cerebral infarction were selected and divided into control group(n=40)and study group(n=40)according to the hospitalization number(odd number/even number).Both groups were given conventional treatments such as thrombolysis,anti-platelet aggregation,and prevention of cerebral edema.On this basis,the control group was treated with Ginkgo leaf extract dipyridamole injection,while the study group was treated with Edaravone injection on the basis of that of the control group.Both groups were treated for 14 days.The clinical efficacy,the levels of plasma homocysteine(Hcy)and high-sensitivity C-reactive protein(hs-CRP)before and after the treatment,the National institute of health stroke scale(NIHSS)score,the Glasgow outcome score(GOS),the activities of daily living(ADL)score,and the occurrence of adverse reactions were compared between the two groups.Results:After the treatment,the total effective rate of treatment in the study group was 97.50%,which was higher than the control group of 80.00%,and the difference was statistically significant(P<0.05).The Hcy and hs-CRP levels of the study group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).The NIHSS score of the study group was lower than that of the control group;the GOS and ADL scores were higher than those of the control group;and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Edaravone combined with Ginkgo leaf extract dipyridamole injection has a reliable curative effect in the treatment of acute cerebral infarction.It can reduce the inflammatory reactions and improve the neurological deficit symptoms with high safety.