高龄短暂性脑缺血发作患者应用氯吡格雷与阿司匹林序贯治疗及对免疫功能的影响

Sequential treatment of elderly patients with transient ischemic attack with clopidogrel and aspirin and its influence on immune function

目的:探讨高龄短暂性脑缺血发作(TIA)患者应用氯吡格雷与阿司匹林序贯治疗及对免疫功能的影响。方法:2018年7月-2020年7月收治高龄TIA患者72例,依据不同治疗方式分两组,各36例。对照组使用阿司匹林治疗;研究组使用氯吡格雷与阿司匹林序贯治疗。比较两组治疗效果。结果:研究组治疗总有效率高于对照组,且复发率低于对照组,差异有统计学意义(P<0.05);研究组治疗后CD4^(+)、CD4^(+)/CD8+水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。结论:联合使用氯吡格雷及阿司匹林序贯治疗高龄TIA患者,可显著提高临床效果,并提高患者的免疫功能,且安全性高。

Objective:To explore the sequential treatment of elderly patients with transient ischemic attack(TIA)with clopidogrel and aspirin and its influence on immune function.Methods:From July 2018 to July 2020,72 elderly patients with TIA were selected and divided into two groups with 36 cases in each group.The control group was treated with aspirin.The study group was treated with sequential treatment of clopidogrel and aspirin.We compared the therapeutic effects of the two groups.Results:The total effective rate of the study group was higher than that of the control group,and the recurrence rate was lower than that of the control group,the difference was statistically significant(P<0.05).In the study group,after treatment,the levels of CD4^(+),CD4^(+)/CD8+were higher than those in the control group,while the CD8+level was lower in the study group,the difference was statistically significant(P<0.05).Conclusion:Combined use of clopidogrel and aspirin sequential treatment of elderly patients with TIA can significantly improve the clinical effect,and improve the immune function of patients,and it has high safety.