全胸腔镜肺叶切除术中局部应用洛铂治疗肺癌的疗效分析

Analysis on the effect of local application of lobaplatin in the treatment of lung cancer in total thoracoscopic lobectomy

目的:研究全胸腔镜肺叶切除术中局部应用洛铂治疗肺癌的价值。方法:2018年7月-2020年5月收治行全胸腔镜肺叶切除术治疗的肺癌患者54例,随机分为两组,各27例。研究组术中局部应用洛铂;对照组仅行手术治疗。比较两组临床疗效。结果:研究组病灶缓解率显著高于对照组,差异有统计学意义(P<0.05);研究组患者出院时生活质量评分优于对照组,差异有统计学意义(P<0.05);研究组随访1年后生存率高于对照组,差异有统计学意义(P<0.05)。结论:在全胸腔镜肺叶切除术中,局部应用洛铂治疗肺癌患者,有利于病情的缓解和生活质量的改善,术后1年生存率得到提升,且不增加不良反应发生率。

Objective:To study the value of local application of lobaplatin in the treatment of lung cancer in total thoracoscopic lobectomy.Methods:From July 2018 to May 2020,54 cases of patients with lung cancer who underwent total thoracoscopic lobectomy were enrolled,they were randomly divided into two groups with 27 cases in each group.The study group locally applied lobaplatin during operation,while the control group received only surgical treatment.The therapeutic effects between the two groups was compared.Results:The remission rate of the study group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).The quality of life score in the study group was better than that in the control group upon discharge,the difference was statistically significant(P<0.05).The survival rate of the study group after 1 year of follow-up was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:In total thoracoscopic lobectomy,the local application of lobaplatin in the treatment of lung cancer patients is beneficial to the remission of the disease and the improvement of quality of life.The 1-year survival rate is improved and the incidence of adverse reactions is not increased.