免疫检查点抑制剂对甲状腺功能影响的研究进展

Research progress of thyroid dysfunctions during treatment with immune-checkpoint inhibitors

甲状腺功能紊乱(thyroid dysfunction,TD)是癌症患者在接受免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)治疗过程中最常见的内分泌系统免疫相关不良事件(immune related adverse events,IRAEs)之一。本文主要从免疫治疗相关性甲状腺功能紊乱的发病机制、流行病学、诊疗方面、预后展望进行介绍,使更多内分泌科医师和肿瘤科医师认识、掌握免疫治疗相关甲状腺疾病的临床特点和诊疗策略,加强科间合作,以减轻癌症患者免疫抑制剂治疗过程中遭受的甲状腺不良事件带来的影响。

Thyroid dysfunction(TD)is one of the commonest endocrine immunotherapy-related adverse events(IRAEs)during cancer patients'treatment with immune checkpoint inhibitors(ICIs).In the hope that cooperation between departments will be enhanced to alleviate the side effect of immunotherapy which thyroid dysfunctions can cause,this review is contributed to make more endocrinologists and oncologists acknowledge and master clinical characteristics,diagnostic methods and therapeutic strategies of thyroid IRAEs,by the introduction of its pathogenesis,epidemiological features,diagnosis,treatment and prognosis.