鲍曼不动杆菌耐药率与上一年度抗菌药物使用强度之间的相关性

Relationship between the resistance rate of Acinetobacter baumannii strains and the antibacterials use density in the previous year

目的研究鲍曼不动杆菌的耐药率与提前1年抗菌药物使用强度(AUD)之间的相关性。方法运用SPSS 21.0软件,将2013-2018年鲍曼不动杆菌的耐药率与提前1年的AUD之间进行Pearson相关分析。结果共分离出鲍曼不动杆菌1803株。通过Pearson相关分析,鲍曼不动杆菌对头孢他啶的耐药率与上一年度左氧氟沙星、美罗培南的AUD正相关,特别是与美罗培南的AUD之间呈高度正相关(P <0.01);鲍曼不动杆菌对亚胺培南的耐药率与上一年度庆大霉素的AUD正相关。结论鲍曼不动杆菌的耐药率与上一年度AUD之间存有一定的相关性,临床应加强抗菌药物的合理使用,降低AUD。

AIM To study the correlation between the drug resistance rate of Acinetobacter baumannii and the use antibacterials use density(AUD) in the previous year. METHODS SPSS 21.0 software was used to analyze the Pearson correlation between the drug resistance rate of Acinetobacter baumannii in 2013-2018 and the AUD one year in advance. RESULTS A total of 1 803 strains of Acinetobacter baumannii were isolated. Pearson correlation analysis showed that the resistance rate of Acinetobacter baumannii to ceftazidime was positively correlated with the AUD of levofloxacin and meropenem in the previous year, especially the AUD of meropenem(P < 0.01). The resistance rate of Acinetobacter baumannii to imipenem was positively correlated with that of gentamicin in the previous year. CONCLUSION There is a certain correlation between the drug resistance rate of Acinetobacter baumannii and the AUD in the previous year. The rational use of antibacterial drugs must be strengthen in clinical practice, so as to reduce their AUD.