成纤维细胞激活蛋白抑制剂在核医学诊疗中的应用

Application of fibroblast activation protein inhibitors in the diagnosis and treatment of nuclear medicine

成纤维细胞激活蛋白(FAP)在大多数上皮来源恶性肿瘤中高表达,FAP抑制剂(FAPIs)已用于肿瘤治疗。以FAP为靶点,可开发一类新的肿瘤显像及治疗放射性药物,FAPIs作为肿瘤显像及治疗的载体已被用于临床前及临床研究。该文对FAPIs在核医学显像及治疗中的研究进展进行综述。

Fibroblast activation protein(FAP)is highly expressed in most epithelial tumors,and FAP inhibitors(FAPIs)have been used in tumor diagnosis and treatment.Taking FAP as the target,new kinds of tumor imaging and therapeutic radiopharmaceuticals can be developed.FAPIs have been used in the preclinical and clinical researches as the carrier of tumor imaging and treatment.This article reviews the research progress of FAPIs in nuclear medicine imaging and treatment.