肝移植领域国家自然科学基金项目10年资助情况

Analysis of projects in liver transplantation by National Natural Sciences Foundation of China from 2010–2019

目的通过分析肝移植领域国家自然科学基金资助的项目情况,梳理总结肝移植领域基础研究的基本情况和研究重点,为今后科研人员申请项目和项目资助提供数据基础。方法检索国家自然科学基金大数据知识管理服务门户平台、科学基金网络信息系统和国家自然科学基金共享服务网2010–2019年期间肝移植相关领域的资助项目信息,分析青年基金对肝移植领域青年科研人才培养方面的资助成效,重点分析学科申请代码体系下资助项目的研究重点和发展方向。结果2010–2019年期间国家自然科学基金持续稳定资助肝移植领域基础研究,资助项目总数387项,资助经费19821.5万元。项目类型以面上项目、青年基金和地区基金为主。其中面上项目210项(54.3%),金额为11314.0万元(57.1%);青年基金127项(32.8%),金额为2790.0万元(14.1%);地区基金22项(5.7%),金额为903.0万元(4.6%)。中山大学和浙江大学无论是承担项目总数还是获资助经费均遥遥领先于其他依托单位,青年/面上比值最高达到了72.2%(13/18),青年基金项目向更高层次项目转化率高达50%左右,显著高于肝移植领域总体水平的24.7%(21/85)。资助项目主要集中于申请代码H0321(消化系统器官移植)169项(43.7%)、H0318(肝再生、肝保护、肝衰竭、人工肝)58项(15.0%)和H1006(器官移植与移植免疫)50项(12.9%)。研究方向以移植免疫、肝损伤与肝保护尤为突出;与此同时,移植物功能、肝移植并发症等项目也有资助。目前缺少长期存活患者肝移植后免疫状态、免疫抑制剂相关疾病的机制和防治等方面的研究。结论国家自然科学基金对肝移植的学科发展、研究人才结构和人才梯队建设具有巨大的引领效应,但资助存在学科布局欠合理,缺少对长期移植物功能、慢性免疫排斥的机制和防治等方面的关注。

Objective In order to provide a data base for fund project applicants and funding priorities,we would summarize the basic situation and key points of basic research in liver transplantation by analyzing the projects funded by the Natural Science Foundation of China(NSFC)in the field of liver transplantation.Methods Through the big data knowledge management and service platform of NSFC,internet-based science information system,and shared service network of NSFC,we searched the funding project information in the liver transplantation relevant field from 2010 to2019,then analyzed the effectiveness of the Young Scientists Fund of NSFC in promoting young researchers and the research focus and development direction of funding projects.Results In the latest 10 years,NSFC persistently and stably funded the basic research in the field of liver transplantation,with the total number of funding projects was 387,and the funding budget was 198.215 million yuan.The main types of funding projects were the General Program and the Youth Science Fund.There were 210 General Program project(54.3%)with an amount of 113.14 million yuan(57.1%),127 Young Scientists Fund(32.8%)with an amount of 27.9 million yuan(14.1%),and 22 Fund for Less Developed Regions(5.7%)with an amount of 9.03 million yuan(4.6%).Sun Yat-sen University and Zhejiang University were far ahead of other supporting institutions in both the total number of projects undertaken and the amount of funds granted.The youth/surface ratio reached as high as 72.2%(13/18).The conversion rate of Young Scientists Fund to higher-level projects reached about 50%,which was significantly higher than the overall level of 24.7%(21/85)in the field of liver transplantation.The funding projects were mainly distributed in application code H0318(liver regeneration,liver protection,liver failure,and artificial liver,58,15.0%),H0321(organ transplantation of digestive system,169,43.7%),and H1006(organ transplantation and transplantation immunity,50,12.9%).The main research fields were transplantation immunity and liver injury and liver protection.At the same time,projects such as graft function and complications of liver transplantation were also funded.There were few studies on the immune status of long-term survival in patients after liver transplantation and the mechanism on prevention of immunosuppressant-related diseases.Conclusions The NSFC has a great leading effect on the discipline development and talent cultivation of liver transplantation.However,there are still some problems in the discipline layout,such as the lack of attention to the mechanism of long-term graft function and chronic immune rejection.