术后骨饥饿综合征

Postoperative hungry bone syndrome

目的总结甲状旁腺功能亢进症患者行甲状旁腺切除后发生骨饥饿综合征(hungry bone syndrome,HBS)的机制、危险因素、临床表现及内科治疗,以期为临床医师提供疾病诊疗参考。方法收集HBS相关的文献并结合临床经验进行综述。结果 HBS是术前存在高骨转换状态患者行甲状旁腺切除术后以低钙血症为主要表现的一组临床综合征,发生率较高,主要通过补充钙剂及维生素D制剂达到治疗目的。结论 HBS需临床医师合理诊断、及时治疗,通过内科治疗可使患者达到长期的血钙磷稳定及骨量增长。

Objective To summarize the mechanism,risk factors,clinical manifestations,and medical treatment of hungry bone syndrome(HBS)in patients with hyperparathyroidism after parathyroidectomy,and to provide clinicians with reference for disease diagnosis and treatment.Method The related literatures about HBS in patients were collected and reviewed with clinical experience.Results HBS was a group of clinical syndromes mainly manifested as hypocalcemia after parathyroidectomy in patients with high bone turnover state before operation,with a high incidence,and the main purpose of treatment was achieved by supplementing calcium and vitamin D.Conclusions HBS requires reasonable diagnosis and timely treatment by clinicians.Patients can achieve long-term blood calcium and phosphorus stability and bone mass growth through medical treatment.