大承气汤联合西药治疗重症急性胰腺炎的临床效果研究

Clinical effect of Dachengqi Decoction combined with western medicine in the treatment of severe acute pancreatitis

目的:探讨大承气汤联合西药治疗重症急性胰腺炎(SAP)的临床疗效。方法:2017年3月-2020年3月收治SAP患者50例,按照治疗方案不同分为两组,各25例。对照组给予常规西药治疗,观察组给予大承气汤联合西药治疗,比较两组治疗效果。结果:观察组治疗后中医症状积分明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后白介素-6(IL-6)、肿瘤坏死因子(TNF-α)及血清淀粉酶(AMY)水平均明显低于对照组,差异有统计学意义(P<0.05);观察组症状缓解时间、排便恢复时间及住院时间均明显短于对照组,差异有统计学意义(P<0.05)。结论:大承气汤联合常规西药治疗SAP,可有效缓解患者症状,促进病情转归。

Objective:To explore the clinical effect of Dachengqi Decoction combined with western medicine in the treatment of severe acute pancreatitis(SAP).Methods:From March 2017 to March 2020,50 SAP patients were selected,and they were divided into two groups with 25 cases in each group according to different treatment schemes.The control group was given conventional western medicine.The observation group was given Dachengqi Decoction combined with western medicine.We compared the therapeutic effects of the two groups.Results:In the observation group,after treatment,the TCM symptom score was significantly lower than that in the control group,the difference was statistically significant(P<0.05).In the observation group,after treatment,the levels of interleukin-6(IL-6),tumor necrosis factor(TNF-α)and serum amylase(AMY)were significantly lower than those in the control group,the difference was statistically significant(P<0.05).In the observation group,the symptom relief time,defecation recovery time and hospitalization time were significantly shorter than those in the control group,the difference was statistically significant(P<0.05).Conclusion:Dachengqi Decoction combined with conventional western medicine in the treatment of SAP can effectively relieve the symptoms of patients and promote the prognosis of the disease.