高压氧联合左卡尼汀对男性少弱精症试管婴儿助孕的疗效观察

Effect of hyperbaric oxygen combined with levocarnitine on assisted pregnancy in vitro in men with oligospermia.

目的研究高压氧联合左卡尼汀应用在男性少弱精症试管婴儿助孕中的临床效果。方法采用回顾性分析,研究对象为2018年7月至2020年8月东莞市松山湖中心医院门诊收治的90例男性少弱精症患者,按照治疗方法不同将其分为3组,每组各30例。左卡尼汀组单用左卡尼汀治疗,高压氧组单用高压氧治疗,联合治疗组联用高压氧与左卡尼汀治疗。比较治疗前、治疗1个月后3组患者性激素水平、精子质量变化,随访观察3个月试管婴儿助孕成功率、早期流产率。结果治疗前,3组间各观察指标比较,差异均无统计学意义(P>0.05)。治疗1个月后,各组性激素水平、精子质量均较治疗前明显改善,差异有统计学意义(P<0.05),且联合治疗组较左卡尼汀组、高压氧组性激素水平、精子质量、试管婴儿助孕成功率更高,早期流产率更低,差异有统计学意义(P<0.05);而左卡尼汀组与高压氧组各观察指标比较,差异均无统计学意义(P>0.05)。结论在男性少弱精症试管婴儿助孕中,高压氧联合左卡尼汀的应用效果显著,可进一步提升患者性激素水平、精子质量及试管婴儿助孕成功率,且可降低早期流产率。

Objective To study the effect of hyperbaric oxygen combined with levocarnitine in IVF assisted pregnancy with male oligospermia.Methods Using a retrospective analysis method,the research object was 90 male patients with oligospermia who were admitted to the outpatient clinic of Dongguan Songshan Lake Central Hospital from July 2018 to August 2020.They were divided into three groups according to treatment methods,with 30 cases in each.The levocarnitine group was treated with levocarnitine alone,the hyperbaric oxygen group was treated with hyperbaric oxygen alone,and the combined treatment group was treated with hyperbaric oxygen and levocarnitine.Changes in sex hormone levels and sperm quality of the three groups of patients before treatment and after one month treatment were compared.The success rate of IVF assisted pregnancy and the rate of early abortion were observed after 3 months of follow-up.Results Before treatment,there was no significant difference between the three groups of observation indicators(P>0.05).After treatment,the levels of sex hormones and sperm quality in each group were significantly improved compared to before treatment(P<0.05),and the combined treatment group had higher sex hormone levels,sperm quality,and IVF success rate than the L-carnitine group and hyperbaric oxygen group,the rate of early miscarriage was lower(P<0.05);and there was no significant difference in the observation indexes between the L-carnitine group and the hyperbaric oxygen group(P>0.05).Conclusion The effect of hyperbaric oxygen combined with L-carnitine in IVF in males with oligoasthenospermia is significant,which can further improve the patient's sex hormone level,sperm quality and IVF success rate,and can reduce the early abortion rate.