血清单胺氧化酶与儿童青少年肥胖之间的关系研究

Relationship between serum monoamine oxidase and obesity in children and adolescents

目的探究血清单胺氧化酶水平与儿童青少年肥胖程度及其与心血管代谢指标之间的关系,为肥胖及其相关并发症的预防和治疗提供理论依据。方法于2018年4-11月对沈阳市1007名中学生进行体检,包括身体测量和血清生化指标检测,并根据不同肥胖等级分组进行分析。结果研究对象中肥胖率为14.40%,男性高于女性(16.33%vs.12.48%)。单因素方差分析结果显示,肥胖组血清单胺氧化酶浓度比正常组高出16.32%[(8.48±2.10)U/L vs.(7.29±3.02)U/L,F=9.874,P<0.001];Logistic回归分析结果显示血清单胺氧化酶水平升高是发生肥胖的危险因素(OR=1.13,95%CI:1.06~1.20,P<0.001);线性相关与回归分析发现血清单胺氧化酶水平与休重指数(β=0.083,95%CI:0.025-0.140,P=0.005)及门冬氨酸氨基转移酶(β=0.039,95%CI:0.003~0.075,P=0.032)水平相关。结论血清单胺氧化酶水平升高是肥胖发生的危险因素,血清单胺氧化酶可能参与了脂代谢、糖代谢等与肥胖相关的生理过程。

Objective To explore the relationship between serum monoamine oxidase level and obesity in children and adolescents and its correlation with cardiovascular and metabolic indexes,so as to provide theoretical basis for prevention and treatment of obesity and its related complications.Methods Totally 1007 middle school students from Shenyang city were enrolled in this study to perform physical examination from April to Norember 2018,including body measurements and serum biochemical tests.And the results were analyzed according to different levels of obesity group.Results The rate of obesity was 14.40%,which was significantly higher in boys(16.33%)than girls(12.48%).One-way ANOVA showed that of the serum monoamine oxidase level of the obese group was higher than that of the normal by 16.32%[(8.48±2.10)U/L for obese group and(7.29±3.02)U/L for normal group,F=9.874,P<0.001].Logistic regression analysis showed that the increase of serum monoamine oxidase was a risk factor for obesity(OR=1.13,95%CI:1.06-1.20,P<0.001).Linear correlation and regression analysis showed that the serum monoamine oxidase level was correlated with body mass index(β=0.083,95%CI:0.025-0.140,P=0.005)and AST level(β=0.039,95%CI:0.003-0.075,P=0.032).Conclusion Serum monoamine oxidase might be involved in some physiological processes related to obesity such as fat metabolism and sugar metabolism,so that the increase of serum monoamine oxidase is a risk factor for obesity.