南京市0~3岁婴幼儿25羟维生素D缺乏与贫血关系的研究

Relationship between 25-hydroxyvitamin D deficiency and anemia in infants aged 0 to 3 years in Nanjing

目的分析南京市0~3岁婴幼儿25羟维生素D[25-(OH)D]水平,并研究其与贫血的相关性,为儿童贫血防治提供理论依据。方法选取江苏省人民医院妇幼分院儿童保健门诊2017年8月-2019年10月共1143例常规体检的0~3岁婴幼儿,对其末梢血25-(OH)D、血红蛋白(Hb)结果进行统计分析;并分析各年龄段25-(OH)D水平与Hb的相关性。结果1143例0~3岁婴幼儿25-(OH)D平均水平为(79.03±25.71)nmol/L,其中缺乏者113例(9.88%),不足者451例(39.46%),充足者579例(50.66%);不同年龄段25-(OH)D水平差异有统计学意义(F=25.26,P<0.01),以2~3岁组水平最低;贫血者122例(10.67%),非贫血者1021例(89.33%),25-(OH)D缺乏组贫血检出率明显高于充足组,差异有统计学意义(F=8.261,P=0.004);Pearson相关性分析发现25-(OH)D水平与Hb在0~、0.5~、1~2岁组均存在正相关性(r=0.288,0.274,0.123,P<0.05),2~3岁组未发现相关性(r=0.080,P=0.264)。结论南京市0~3岁婴幼儿25-(OH)D总体缺乏和不足率较高;0~2岁年龄段婴幼儿25-(OH)D水平与Hb存在正相关性,提示25-(OH)D缺乏可能影响Hb的生成,与婴幼儿贫血的发生相关。

Objective To analyze the level of 25 hydroxyvitamin D[25-(OH)D]in infants aged 0-3 years in Nanjing,and to explore its correlation with anemia.Methods A total of 1143 children aged 0-3 years old who underwent routine physical examination in the children health clinic of women and children′s branch of Jiangsu Province Hospital from August 2017 to October 2019 were enrolled in this study.The levels of 25-(OH)D and hemoglobin(Hb)of peripheral blood were tested and the correlation between the level of 25-(OH)D and Hb in different age groups was analyzed.Results The average level of 25-(OH)D was(79.03±25.71)nmol/L in 1143 infants aged 0~3 years,among whom 113(9.88%)were deficient,451(39.46%)were insufficient,and 579(50.66%)were adequate.The difference on 25-(OH)D level in different age groups was significant(F=25.26,P<0.01),with the lowest level in the 2 to 3 years old group.122 cases(10.67%)suffered from anemia,and 1021 cases(89.33%)were non-anaemic.The detection rate of anemia in 25-(OH)D deficiency group was significantly higher than that in adequate group(χ~2=8.261,P=0.004).Pearson correlation analysis showed that there was a positive correlation between the level of 25-(OH)D and Hb in the groups of 0 to 0.5 year old,0.5 to 1 year old,and 1 to 2 years old(r=0.288,0.274,0.123,P<0.05),while no correlation was found in the group of 2 to 3 years old(r=0.080,P=0.264).Conclusions The overall rate of 25-(OH)D deficiency and insufficiency is relatively high in infants aged 0 to 3 years in Nanjing.And there is a positive correlation between the level of 25-(OH)D and Hb in infants aged 0 to 2 years,suggesting that the lack of 25-(OH)D may affect the generation of Hb and be related to the occurrence of anemia in infants.