医药副产含磷废盐的提纯研究

Study on purification of phosphorus waste salt produced by medicine

随着精细化工及中间体产品的发展,各类副产废盐量不断增加,由于其产生量大及难处理等特点,成为阻碍行业发展的一大瓶颈。主要开展了医药副产含磷废盐的提纯实验研究,针对废盐产生的途径和特性,采用洗脱剂(甲醇-乙醇)+活性炭混合洗脱与重结晶的方式,分别去除废盐中的有机物和氯化钠,回收可利用的磷酸盐,实现废盐的提纯资源化。当洗脱剂与废盐的体积质量比为1 mL/g、洗脱剂甲醇与乙醇的体积比为4∶6、活性炭用量为废盐质量的0.4%时,废盐中的有机物得到了有效去除。随后对得到的混盐进行重结晶得到回收磷酸盐,回收磷酸盐的纯度可达98%以上,符合工业磷酸盐行业标准的要求。将含磷废盐提纯回收磷酸盐,1 t废盐的处理成本约为174.24元,可回收0.61 t磷酸盐,实现了废盐的资源化再利用。

With the development of fine chemicals and intermediate products,the amount of various types of by-product waste salts continues to increase.Due to its large volume and difficult to be treated,it has become to be a critical bottleneck that hinders the development of the industry.The purification experimental study of phosphorus-containing waste salt produced as byproduct of medicine was carried out.According to the generation method and characteristics of waste salt,methanol/ethanol mixed with activated carbon were used to remove organic matter and sodium chloride in waste salt by elution and recrystallization.When the volume to mass ratio of eluent to waste salt is 1 mL/g,the volume ratio of eluent methanol to ethanol is 4∶6,and the mass dosage of activated carbon to the waste salt is 0.4%,the organism in the waste salt has been removed effectively.Subsequently,the obtained mixed salt is recrystallized with the purity of phosphate more than 98%,which meets the industrial phosphate standard.The treatment cost of waste salt is about 174.24 RMB/t and 0.61 t of phosphate can be reco-vered by the above purification and recovery process,realizing the reuse of waste salt.