亚急性砷中毒11例临床分析

Clinical analysis of 11 cases of sub-acute arsenic poisoning

目的分析亚急性砷中毒的临床特点和治疗效果。方法2020年1月,回顾性分析一起砷矿渣污染饮用水致亚急性砷事件中毒事件,总结亚急性砷中毒的临床特点和治疗效果。结果11例饮水型亚急性砷中毒患者早期表现为急性胃肠炎,部分有皮肤、血液、肝脏、肾脏、心血管等多器官损害,后期以周围神经系统损害为主。治疗以驱砷、保护靶器官和治疗中毒性周围神经病为主,疗效较好,但重度中毒性周围神经病恢复较慢。结论经消化道吸收所致亚急性砷中毒早期以急性胃肠炎表现为主,早诊早治,疗效较好,但重度中毒性周围神经病恢复较慢。

Objective To investigate the clinical manifestations,treatments and prognosis of subacute arsenic poisoning.Methods In January 2020,a retrospective analysis was carried out on 11 patients hospitalized with subacute arsenic poisoning caused by arsenic contaminated drinking water.We observed manifestations,treatments and prognosis.Results The main clinical presentations of subacute arsenic poisoningin were gastroenteritis in early phase,some of them had other organ damage,such as skin,blood,liver,kidney,cardiovascular and so on.The later phase was mainly peripheral nervous system damage.The treatment was mainly to chelate arsenic,protect target organs and treat toxic peripheral neuropathy.Most were significantly recoveried,but the recovery of severe toxic peripheral neuropathy was tardy.Conclusion Acute gastroenteritis is the mainly early manifestation of subacute arsenic poisoning caused by digestive tract,and toxic peripheral neuropathy in the later phase.The prognosis is good,but the recovery of severe toxic peripheral neuropathy is tardy.